Project Grant RF1AG077658
Award Date
6/1/22
Completion Date
5/31/25
Dollars Obligated
$4.5M
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Missouri, USA
Similar Awards
This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,638,424 to the University of California, San Diego from August 1, 2022 to July 31, 2025. The grant will support research developing novel quantitative magnetic resonance imaging techniques to directly image myelin and quantify myelin content and properties in the brain. Specifically, the researchers will use ultra-short echo time sequences with echo...
This $481,250 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The 2-year project at Vanderbilt University Medical Center (VUMC) has three key objectives: 1) verifying the dependency of the MRI signal on lipid properties using reconstituted phospholipid samples and cultured cells; 2) confirming the origin of the MRI signal in AD...
This $254,250 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine will develop a biologically relevant multi-scale model of brain aging using advanced diffusion magnetic resonance imaging (dMRI) techniques. The project aims to create brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan to establish a brain microstructure age framework. In the second phase, the researchers will...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research initiative led by Yale University to identify early biomarkers for Alzheimer's disease using advanced neuroimaging techniques. The $460,548 award will fund a longitudinal study that utilizes multi-modal MRI and MRS imaging, along with behavioral testing, to characterize the functional connectivity and mitochondrial energy metabolism changes in the olfactory and memory circuits of an...
The National Institutes of Health National Institute on Aging awarded $4,575,712 under the Aging Research program (CFDA 93.866) to The Washington University from May 2022 to April 2025. The award will support research into white matter metabolism in the context of aging, white matter hyperintensities, and Alzheimer's disease. Investigators will apply quantitative positron emission tomography imaging techniques to measure cerebral oxygen consumption, blood flow, oxygen extraction fraction, and...
The National Institute on Aging (NIA) awarded a $1,783,700.00 Project Grant under the Aging Research program (CFDA 93.866) to the University of Illinois to develop novel blood-brain barrier permeable multimodal imaging agents for the diagnosis of neurodegenerative diseases, with a focus on Alzheimer's disease and related dementias. The 3-year grant aims to employ organic and inorganic chemical design principles to generate diagnostic agents capable of detecting protein aggregation,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop and optimize non-invasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The $812,030 award, effective from December 2024 to November 2029, supports research focused on three key objectives: Investigating the relationship between astrocytic acetate metabolism and astrocyte reactivity in an AD model using deuterium-based magnetic resonance...