Project Grant R01AG091760
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $759,352 to investigate how shifts in microglial metabolism impact the progression of Alzheimer's disease (AD) and whether targeting metabolic flux can reduce AD-related pathology. The research aims to elucidate the role of lactate, a byproduct of glycolysis, in regulating immunometabolism and microglial activity in the context of AD. The 5-year award, starting on May 15,...
- This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This Project Grant award of $497,878 from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will fund a Phase 0 study to evaluate the in vivo characteristics of a myeloperoxidase (MPO)-targeting PET imaging agent (18F-EH301) in healthy volunteers and early Alzheimer's disease (AD) patients. The study aims to develop a PET imaging tool that can detect and track neuroinflammation, a key early event in the development of AD, by specifically targeting...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,249,957 Project Grant under CFDA 93.866 (Aging Research) to Advantage Therapeutics, Inc. in Florida. The grant aims to perform IND-enabling studies on a small molecule that is disease-modifying, low-cost, and has a long safety record for the treatment of Alzheimer's disease. The proposed molecule is designed to reduce brain inflammation and restore phagocytosis, thereby improving the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $487,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Pennsylvania on Aug 15, 2025. The grant supports research to develop an in vivo CRISPR screening platform to identify genetic regulators of microglial phagocytosis in Alzheimer's disease (AD). Key objectives include: Investigating microglial phagocytosis of amyloid in combination with amyloid-targeting...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- This Project Grant award of $1,602,696 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the relationship between obesity, cognitive impairment, and neurological disorders such as Alzheimer's disease. The research aims to use magnetic resonance imaging (MRI) techniques to assess neurovascular and lymphatic changes, neuroinflammation, and blood-brain barrier dysfunction in mouse models of obesity-linked cognitive decline. The goal is to identify...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research provides $812,030 to develop and optimize non-invasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The research aims to investigate the relationship between astrocytic acetate metabolism and astrocyte reactivity, characterize spatiotemporal patterns of neuroinflammation and brain glucose hypometabolism in an AD mouse model, and validate the efficiency of these imaging methods by assessing the impact of a ketogenic diet on neuroinflammation in AD mice. The award was granted on Dec 15, 2024 with an ultimate completion date of Nov 30, 2029. The research will be conducted by the University of Pennsylvania, with a sub-award to The Children's Hospital of Philadelphia to provide expertise on the design and construction of adeno-associated virus (AAV) vectors for the project.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $812.0k | 12/10/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
501936S | The Children's Hospital Of Philadelphia | Project Grant R01AG091760 | $47.9k | 1/28/25 |