This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Neuroscope Inc. in the amount of $1,193,370 aims to develop a computational toolset for mapping and quantifying perivascular space (PVS) morphology from MRI. The goal is to create a non-invasive, automated method to assess PVS, which is an important diagnostic feature for Alzheimer's disease and vascular dementia. The funded work will build the IT infrastructure to commercialize Neuroscope's PVS...
This Project Grant award of $4,361,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports a multi-institutional effort led by the Washington University to investigate the molecular mechanisms underlying cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID). The project leverages three key resources: a large collection of cerebrospinal fluid samples, human brain tissue specimens, and advanced neuroimaging analytical pipelines. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,906 to the University of Wisconsin - Madison to elucidate cerebrovascular disease pathways contributing to cognitive decline. The 5-year project, effective June 1, 2025, aims to leverage advanced neuroimaging techniques to characterize dynamic vascular and hemodynamic factors, such as intracranial vascular stiffness and neurovascular flow tone, that may impact brain tissue integrity and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $1,017,307 to the University of Illinois to investigate the use of magnetic resonance elastography (MRE) to predict characteristics and tissue reexpansion of chronic subdural hematomas (CSDH). The project will examine 40 CSDH patients, collecting clinical measures of hematoma size and density, as well as high-resolution MRE data to map brain stiffness and damping ratio. The researchers will...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to create an inter-Alzheimer's Disease Research Center (ADRC) set of objectively measured cerebral small vessel disease (SVD) magnetic resonance imaging (MRI) biomarkers from large and diverse clinical cohorts. The $790,491 award will fund the development and validation of novel deep-learning methods to accurately quantify SVD biomarkers, including cerebral microbleeds, white matter...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $9,631,026 to Northwestern University to conduct a comprehensive analysis of the impact of atherosclerosis on the brain's microvasculature in the context of Alzheimer's disease (AD). The research aims to deepen the understanding of the relationship between vascular health and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $2,317,887 will be used by Indiana University Indianapolis to map paravascular cerebrospinal fluid (PCSF) signatures associated with healthy aging, aging with hypertension, and Alzheimer's disease (AD). The researchers will leverage dynamic diffusion-weighted imaging, a novel neuroimaging technique, to quantify PCSF dynamics and volume near major arteries - a key component of the glymphatic...
The University of Southern California (USC) was awarded a $4,975,336 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop advanced magnetic resonance imaging (MRI) techniques for mapping and quantifying cerebral small vessels as imaging biomarkers of vascular cognitive impairment and dementia (VCID). The project aims to optimize acquisition protocols and analysis pipelines for black-blood and arterial spin labeling MRI at 3 Tesla to comprehensively...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $136,778 to Wake Forest University Health Sciences to conduct research on the impacts of cerebral small vessel disease on brain networks and cognitive impairment. The key research objectives are to: 1) use advanced brain network modeling to quantify the resilience and disruption caused by cerebral microbleeds, 2) develop an integrative machine learning model to improve prediction...
The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...