Project Grant R21AG083965
Award Date
6/15/24
Completion Date
5/31/26
Dollars Obligated
$468K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
Similar Awards
This $461,146 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project at Yale University to investigate the disruption of astrocytes, a key cell type in the brain, across different stages of Alzheimer's disease pathology. The project aims to utilize advanced imaging techniques to longitudinally track changes in astrocytic signaling and its coupling with neuromodulatory systems, such as noradrenergic signaling, in two genetic models of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop and optimize non-invasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The $812,030 award, effective from December 2024 to November 2029, supports research focused on three key objectives: Investigating the relationship between astrocytic acetate metabolism and astrocyte reactivity in an AD model using deuterium-based magnetic resonance...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $372,690 to The Regents of the University of California (UC Berkeley) to conduct research aimed at understanding the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project seeks to develop new statistical methods to uncover the complex relationships between amyloid-beta, tau accumulation, and cognition in different AD subpopulations. The goal is to identify optimal...
This federal Project Grant award, valued at $2,288,327 and provided by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, supports research to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patient samples. The project aims to integrate polygenic risk scores for AD with multi-omic profiling of MCI patient-derived induced neurons (iNs) to better understand the early trajectory of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to investigate the susceptibility of specific cell types within the medial temporal lobe to Alzheimer's disease pathology. The $103,304 grant, awarded on August 1, 2024, will be used by the University of Southern California to identify vulnerable neural circuits originating from the entorhinal cortex and CA1 region of the hippocampus, and characterize the molecular changes in these cell...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to better understand the role of microglia, the brain's immune cells, in the progression of Alzheimer's disease (AD). The University of Washington is the prime awardee and will leverage novel explainable AI techniques and human-induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes occurring early in AD. Specific objectives include using AI to identify...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $452,550.00 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of glial fibrillary acidic protein (GFAP) upregulation in reactive astrocytes and its impact on excitatory tripartite synapses in a tauopathy mouse model of Alzheimer's disease. The award period is from January 1, 2025 to December 31, 2026. The project aims to delineate changes in the protein...
This $2,351,870 Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), aims to develop novel analytical approaches to dissect cell-cell communication among microglia, astrocytes, and neurons, and understand how these communications are dysregulated during Alzheimer's disease (AD) progression. Key products and services to be delivered under this grant include: Developing network-based models and statistical methods to identify...
This federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the role of senescent cells in brain aging and Alzheimer's disease and related dementias (ADRD). The $654,238 award, effective from September 15, 2024 to June 30, 2026, will enable researchers from the University of Texas Health Science Center at San Antonio (UTHSCSA) to generate spatial omics data from ADRD brains and mouse models,...