The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), has been awarded a $452,550 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a research project titled "Reactive Astrogliosis and the Tripartite Synapse in Alzheimer's Disease" over the period of January 1, 2025 to December 31, 2026. The project aims to investigate the role of glial fibrillary acidic protein (GFAP) upregulation in reactive astrocytes and its impact on the structure and protein composition of tripartite excitatory synapses in a tauopathy mouse model of Alzheimer's disease. The findings from this research are expected to elucidate whether GFAP upregulation in reactive astrocytes represents a compensatory mechanism to protect synapses from pathological tau-induced toxicity, which could have therapeutic implications for addressing cognitive decline in Alzheimer's disease.
Generated 2/25/25, 4:18 AM