This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai provides $842,114 to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's disease (AD). The project aims to identify and characterize senescent cells in major subtypes of AD using advanced single-cell multi-omics and spatial transcriptomics techniques. This comprehensive research initiative is...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $118,557 to The University of Texas Health Science Center at San Antonio to study the role of the SNX19 gene in aging brains and Alzheimer's disease. The award aims to investigate the mechanism by which SNX19 contributes to neuropathology, using single-cell analysis of postmortem brain tissue and human-induced pluripotent stem cell-derived brain organoids. The research will examine the link...
This $460,625 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the role of cellular senescence pathways in the pathogenesis of Alzheimer's disease (AD). The award will fund the University of Massachusetts Medical School (UMass Medical) to utilize human induced pluripotent stem cell (iPSC)-based models to independently dissect the impact of the p53/p21 and p16 senescence pathways on AD-related cellular pathologies in differentiated...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,000.00 to the University of Texas Health Science Center at Houston to conduct research on the potential role of cellular senescence as a driver of small vessel disease and post-stroke cognitive impairment in late adulthood. The key objectives are to examine the chronic neurological consequences of small vessel disease following stroke, and to evaluate whether delayed treatment...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $205,619 to the University of Washington from September 2024 to June 2026 to map the landscape of the aged human brain and develop human-based neurodegenerative disease models. The project aims to leverage explainable artificial intelligence (XAI) methods and human brain 'omic data to identify molecular drivers of brain aging, which will then be manipulated in human induced pluripotent...
This National Institute on Aging (NIA) Project Grant award under CFDA Program 93.866 "Aging Research" provides $254,250 to New York University (NYU) School of Medicine to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to create a brain microstructure age framework by generating brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan. It will evaluate the effects of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, San Diego (UCSD) to investigate the mechanisms underlying the generation of new neurons in the aging adult brain. The $126,956 award, running from April 1, 2025 to February 28, 2027, will leverage single-cell spatial transcriptomics to define the pathways of glial cell-to-neuron conversion in aged neurogenic niches. The research aims to identify...
This $125,896 Project Grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a research project led by The Washington University in St. Louis. The project aims to utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and Alzheimer's disease (AD) human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience pathways across genetic, epigenomic,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $794,341 will support research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced progression of Alzheimer's disease. The research will leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human induced pluripotent stem cell (iPSC) models. Key objectives...
The National Institute on Aging (NIA) awarded a $2,288,327 Project Grant (CFDA 93.866 - Aging Research) to the University of California, San Diego (UCSD) on August 15, 2024. The grant funding will support research to investigate the early determinants and pathogenesis of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patient samples. The research teams will utilize patient-derived induced neurons to study how polygenic risk factors and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $654,238 to The University of Texas Health Science Center at San Antonio to study the pathogenic effects of senescent cells on their microenvironments and their role in human brain aging and Alzheimer's disease and related dementias (ADRD).
The key objectives are to: 1) Identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons, 2) Investigate the role of senescent neurons in neuronal death in brain aging and ADRD, 3) Use deep learning models to simulate the deregulation of genes in senescent neurons and predict effects on the microenvironment, and 4) Determine the most promising treatments to mitigate the negative effects of neural senescence. The grant also includes a sub-award to The Washington University to provide collaborative support and expertise in experimental design, data interpretation, and conducting spatial biology experiments and mouse studies.