This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
The National Institute on Aging (NIA) awarded a $188,892 Project Grant under the Aging Research program (CFDA 93.866) to the University of Washington (UW) for the period of January 1, 2025 to December 31, 2027. The goal of this project is to 1) address key gaps in understanding microglial subpopulation responses in individuals resilient to Alzheimer's disease (AD) pathology in both humans and mice, and 2) develop tools and model systems to manipulate specific microglial subpopulations. The...
This $1,761,543 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) supports the "IDEAL-XAI: ADVANCING EXPLAINABLE AI TO IDENTIFY EARLY DRIVER EVENTS OF ALZHEIMER'S DISEASE" research project at the University of Washington. The grant aims to develop innovative explainable AI (XAI) methods that can provide biologically-informed explanations of Alzheimer's disease progression by identifying potential driver genes and mechanisms. Key objectives include...
The National Institute on Aging (NIA) awarded a $661,016 Project Grant (CFDA 93.866 - Aging Research) to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" platform. This project aims to leverage innovative artificial intelligence (AI) techniques and distributed computing to analyze Alzheimer's disease (AD) biobanks from the U.S., India, Japan, and Europe, totaling over 100,000 MRI and PET scans. The key...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $205,619.00 to the University of Washington to conduct research on mapping the landscape of the aged human brain for neurodegenerative disease models. The project aims to leverage explainable artificial intelligence (XAI) methods to identify molecular drivers of brain aging, and then manipulate those drivers in human induced pluripotent stem cell (hiPSC) models to generate aging...
This National Institute on Aging (NIA) Project Grant award under the Aging Research program (CFDA 93.866) provides $460,625 to the University of Massachusetts Medical School (UMass Medical) from September 30, 2024 to September 29, 2026. The project aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). Researchers will use human induced pluripotent stem cell (iPSC)-based AD models to separately dissect the P53/P21 and P16...
This federal Project Grant award, provided by the National Institute on Aging under CFDA 93.866 Aging Research, aims to develop explainable and ethical artificial intelligence (AI) models to assist in the diagnosis and prognosis of Alzheimer's disease (AD). The $738,014 award to Emory University, with a period of performance from August 1, 2024 to April 30, 2029, will leverage the institution's expertise in explainable AI, cerebrospinal fluid proteomics, and understanding the role of factors...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $770,558 project grant to Wake Forest University Health Sciences (WFUHS) for the project "Neuroimage-Genomic Fingerprints for Subtyping and Prediction of Alzheimer's Disease and Related Dementia." The project aims to establish connections between Alzheimer's disease (AD)-related genomic markers and neuroimaging phenotypes to characterize distinctive AD subtypes and develop...
The National Institute on Aging (NIA) awarded a Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regenerative Research Foundation, a non-profit organization, in the amount of $1,931,965 on August 15, 2024. The goal of this award is to generate and validate a novel human induced pluripotent stem cell (iPSC) model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, neural crest pericytes, and microglia to study cerebrovascular...
This $442,357 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) supports research to elucidate the molecular mechanisms underlying the neurodegenerative reprogramming of microglia in Alzheimer's disease (AD). The grant aims to 1) determine how the Integrated Stress Response (ISR) pathway induces chromatin remodeling in microglia, 2) test whether ISR activation exacerbates the stressed phenotypes of microglia in amyloidosis models, and 3) evaluate if ISR...