Project Grant R15NS142899
- Federal Project Grant Award Summary The University of Rhode Island Research Office received an $801,000 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) effective August 1, 2025, through July 31, 2028. This award supports fundamental research investigating toxin activation mechanisms within bacterial toxin-antitoxin (TA) systems, specifically examining how protein quality control factors...
- Federal Project Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $246,999 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026 through March 31, 2031. The grant funds investigator-initiated basic research focused on understanding the molecular mechanisms that modulate DNA repeat expansion instability, a fundamental...
- Federal Grant Award Summary The University of Rhode Island received a $1,142,814 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective August 1, 2025, through June 30, 2030. This T32 Transdisciplinary Training in Biomedical Science and Bioengineering (BSBE) award funds a collaborative predoctoral training program designed to prepare Ph.D.-level graduate students in biomedical sciences and...
- Federal Project Grant Summary The University of Rhode Island received a $597,254 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through April 30, 2029. The award funds a comparative research study investigating the molecular mechanisms by which human beta defensins (HBD-2 and HBD-3) interact with bacterial lipid membranes. The project applies solid-state nuclear...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $460,625 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 18, 2025, with completion targeted for June 30, 2030. This award funds a five-year research initiative investigating how aneuploidy—the presence of abnormal chromosome numbers—drives phenotypic changes across different...
- Federal Project Grant Award Summary Rosalind Franklin University of Medicine & Science received a $396,015 Project Grant award effective January 1, 2026, through December 31, 2030, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research focuses on molecular and cellular regulation of CAV2 voltage-gated calcium channels, which mediate calcium influx at...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Rhode Island a Project Grant totaling $567,224 under the Aging Research program (CFDA 93.866), effective February 1, 2026, through January 31, 2031. The award funds research investigating tissue-specific modulation of mitochondrial DNA (mtDNA) mutations and their role in aging and age-related diseases. The research employs genetic approaches and mouse models to elucidate the mechanisms by which...
- Federal Grant Award Summary The University of Nebraska Board of Regents received a $2.04 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 8, 2025, with completion targeted for July 31, 2029. This award supports fundamental research investigating the ARP2/3 complex—a critical protein assembly system essential to cellular processes including cell migration, tissue...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant of $325,665 under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026, through February 28, 2030. The award supports mechanistic investigations into hydropersulfide (RSSH) donor-mediated rescue of deficient iron-sulfur cluster biosynthesis in Friedreich's Ataxia fibroblasts. The research will examine how RSSH donors...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $435,829 to the University of Massachusetts Medical School, effective June 1, 2026, through January 31, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). This award funds investigator-initiated research examining the mechanisms of gut-brain communication underlying behavioral state transitions, with particular emphasis on how internal physiological...
The University of Rhode Island's Research Office received a $350,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through May 31, 2028. This award funds research to establish a Caenorhabditis elegans (nematode) model system to investigate the molecular etiology of Fanconi Anemia Neurological Syndrome (FANS), a progressive and irreversible neurological disorder affecting patients with Fanconi Anemia. The research employs omics approaches and behavioral paradigms to examine how Fanconi Anemia (FA) protein orthologs influence nervous system function across the lifespan, with specific focus on cholinergic and dopaminergic neuronal subclasses linked to human neurological disorders including autism spectrum disorder, schizophrenia, intellectual disability, and Alzheimer's disease and related dementias. The award supports three primary research objectives: (1) characterizing the roles of FA protein orthologs in nervous system function using behavioral assays linked to neurological disease mechanisms; (2) generating FA animal models expressing fluorescent protein-labeled neuronal populations to enable direct visualization of neuronal development and function; and (3) conducting mechanistic investigations into how defects in genome stability maintenance during neural stem and progenitor cell expansion contribute to nervous system dysfunction. By elucidating the molecular basis of FANS through this model organism research, the project seeks to establish foundational knowledge that could inform future therapeutic approaches for FA patients experiencing neurological decline.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 8/7/25 |