Project Grant R01NS142163
- The federal Project Grant award of $630,414 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research conducted by Northwestern University focused on understanding the role of sodium channel dysfunction in the development of malformations in cortical development (MCDs), which can lead to severe neurological disorders and...
- This federal Project Grant award of $580,619.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the molecular mechanisms of small-conductance calcium-activated potassium (KCa2) channels. The research aims to compare the mechanisms of action for classic positive allosteric modulators (PAMs) and superagonists of KCa2 channels, as...
- This federal Project Grant award, valued at $147,486.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Albert Einstein College of Medicine to understand the impact of CACNA1A/UNC-2 mutations on presynaptic structure and function in the nematode C. elegans. The research aims to investigate how two uncharacterized CACNA1A...
- This federal Project Grant award, valued at $732,475 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to enhance the understanding of Calcium Homeostasis Modulator (CALHM) proteins. These large-pore channels play pivotal roles in diverse biological processes, including neuromodulation, neuroinflammation, taste perception, and...
- This Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) provides $743,995 to the University of Maryland, Baltimore to support research on the role of calcium channel dysfunction in the pathogenesis of neurodevelopmental disorders, including autism spectrum disorder. The research aims to dissect the fundamental mechanisms by which disruption of calcium signaling pathways may underlie these neurological conditions. The 5-year project...
- This federal Project Grant award of $148,614.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research on the role of VAP membrane contact sites in axonal calcium dynamics and synaptic transmission. The research aims to understand how the ER tethering protein VAP and its interaction with voltage-gated potassium channels contribute to calcium signaling and...
- This federal Project Grant award of $812,488 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the conformational dynamics and regulatory mechanisms of the KCNH family of potassium ion channels. The research focuses on understanding the voltage-dependent gating of these channels, including examining the voltage sensor domain and S4 helix, as well as the interactions...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $383,008.00 to The University of Mississippi to conduct computational studies investigating the effects of various mutations in voltage-gated sodium (Nav) channels. The research aims to gain mechanistic insights into how these mutations can lead to a broad spectrum of channelopathies, such as epilepsy, autism, and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate how genetic mutations in the KCNQ2 gene impact the assembly and function of potassium ion channels in neurons. The $874,094 award to Northwestern University, which runs from August 1, 2025 through July 31, 2030, aims to advance the understanding of the...
- This Project Grant award of $5,949,022, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to identify novel therapeutic targets for treating cerebral amyloid angiopathy (CAA) and vascular contributions to cognitive impairment and dementia (VCID). The research, led by the Jackson Laboratory with sub-awards to Emory University, Rush...
This $396,015 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to advance the understanding of CAV2 voltage-gated calcium channels. The research aims to molecularly characterize newly identified genes that regulate CAV2 channel trafficking and degradation, with the goal of improving understanding of CAV2 channelopathies and uncovering potential new therapeutic targets. The award, with a performance period from January 1, 2026 to December 31, 2030, will be carried out by Rosalind Franklin University of Medicine & Science, a private non-profit health sciences university in North Chicago, Illinois with expertise in biomedical research and federal contracting.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $396.0k | 12/29/25 |