Project Grant R01AG092603
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Broad Institute of MIT and Harvard a Project Grant of $610,836 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through May 31, 2030. This award supports research on genetic dissection of mitonuclear interactions in aging and neurodegenerative disease. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale...
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Virginia a $522,167 Project Grant, effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports research investigating mechanisms of ribosomal DNA (rDNA) instability during aging, with the objective of understanding how genomic instability contributes to the aging process. The research focuses on characterizing the roles of the FOB1 protein and...
- Federal Project Grant Award Summary Brown University received a $438,625 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective August 15, 2025, through July 31, 2027. The award funds research to advance understanding of cellular senescence—the biological process in which cells permanently cease dividing in response to molecular damage. The project will investigate how the senescence phenotype evolves across the lifespan of cells,...
- Federal Project Grant Award Summary J. David Gladstone Institutes received a $793,777 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 17, 2025, with a completion date of April 30, 2030. The award funds a comprehensive research project investigating mitochondrial DNA (mtDNA) compaction and the accumulation of somatic mutations with age and stress. The primary deliverable is an enhanced understanding of how mitochondrial...
- Federal Grant Award Summary The National Institute on Aging awarded The Trustees of Columbia University in the City of New York a $690,865 Project Grant (CFDA 93.866 - Aging Research) effective January 15, 2026, with completion targeted for December 31, 2030. This award supports a comprehensive research initiative examining the mitochondrial and energetic underpinnings of resilience in human aging. The research leverages two unique human datasets—the MISBIE Study (which includes patients with...
- Federal Project Grant Award Summary Boston University Medical Campus received $781,008 in project grant funding from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of September 15, 2025 and completion date of June 30, 2030. The grant supports basic scientific research investigating the relationship between transfer RNA (tRNA) modifications and mitochondrial dysfunction in Alzheimer's disease and related dementias (AD/ADRD). The research...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $3.1 million Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh to conduct biomedical research on immune response mechanisms related to persistent DNA damage in aging. The four-year research initiative, which commenced September 1, 2025 and concludes August 31, 2029, focuses on investigating the link between persistent DNA damage and NLRP12 (NOD-Like Receptor 12) expression...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $673,012 Project Grant to the University of Massachusetts, beginning August 15, 2025, and extending through July 31, 2030, under the Aging Research program (CFDA 93.866). This research project will investigate the neuromechanical bases for increased energy cost of walking in older adults, a significant contributor to age-related mobility loss and a major public health concern. The research will examine how...
- Federal Project Grant Award Summary The National Institute on Aging awarded $698,690 to the University of Wisconsin-Madison under its Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This Project Grant supports basic research investigating the molecular mechanisms underlying fiber type-specific skeletal muscle dysfunction in aging populations. The research project will deliver scientific findings and data products examining how aging affects slow...
- Federal Grant Award Summary Rutgers, The State University received a $431,750 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective June 1, 2025, with a completion date of May 31, 2027. The grant funds research investigating the role of mitochondrial deficits in tauopathy-linked autophagy defects as they relate to Alzheimer's disease (AD). The research aims to elucidate the mechanisms by which early mitochondrial...
The National Institute on Aging awarded a Project Grant totaling $567,224 to the University of Rhode Island (effective February 1, 2026, through January 31, 2031) under the Aging Research program (CFDA 93.866) to investigate tissue-specific modulation of mitochondrial deoxyribonucleic acid (mtDNA) mutations and their relationship to aging and age-related diseases. The research will examine how different tissues accumulate and clear mtDNA mutations using genetic approaches and a mouse model designed to control mtDNA mutation development across spatial and temporal dimensions. The study aims to elucidate the mechanisms regulating cellular mtDNA heteroplasmy—the coexistence of multiple mtDNA variants within the same cell—and will evaluate the effects of lifestyle interventions, including exercise and caloric restriction, on mtDNA mutation dynamics across various tissues. This research directly addresses a critical gap in understanding mitochondrial dysfunction resulting from mtDNA mutations, which has been implicated in mitochondrial diseases, neurodegenerative disorders, metabolic syndromes, cancer, cardiovascular diseases, and age-related pathologies. The project's findings are expected to advance scientific knowledge regarding how mtDNA mutations contribute to cellular senescence and aging processes, with potential applications for developing preventive and therapeutic interventions for age-related conditions. The University of Rhode Island Research Office, located in Kingston, Rhode Island, will execute the research activities supported by this award.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $567.2k | 1/28/26 |