Project Grant R35GM160127
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- This $1,970,835 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Chicago focused on the multiscale simulation of key biomolecular processes in the cell. The project will employ bottom-up coarse-grained computational models to study protein-protein interactions, protein-mediated membrane remodeling, and the formation and remodeling of actin-based...
- This federal Project Grant award of $150,104.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a computational framework for investigating the dynamics of actin filament branch formation and aging. The research will focus on understanding the role of nucleotide state and ATP hydrolysis in the actin-related protein (Arp) 2 and Arp3 subunits of the Arp2/3 complex during branch formation,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding the development of novel mass spectrometry technologies to enable rapid, extensive characterization of the structure and heterogeneity of the ribosome. The $340,920 award to the Board of Regents of the University of Nebraska aims to develop advanced techniques for accurate mass determination, efficient...
- This federal Project Grant award of $350,275.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), with a performance period from July 1, 2025 to June 30, 2030. The grant supports a research project at the University of New Mexico (UNM) Health Sciences Center that aims to investigate the molecular mechanisms by which extracellular glucose levels regulate cell mechanics and function. The research...
- This $414,285 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research into the dynamic pattern formation and self-organizing behaviors of the cell cortex. The research aims to elucidate the principles underlying cortical reorganization processes that drive critical cellular functions like cell division, locomotion, and damage response. The primary awardee is the...
- This $640,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to investigate the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications. The project, conducted by the University of New Mexico (UNM) Health Sciences Center, aims to deepen the understanding of how microtubule conformational states and interactions with...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park. The $526,451 grant, awarded on May 1, 2025, supports the development of a novel optical microscopy modality for cell biomechanics research based on pulsed stimulated Brillouin scattering (SBS). The goal is to create a non-contact, non-perturbative, and high-resolution system to study the...
- This federal Project Grant award of $294,147 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance modeling of macromolecular interactions in living cells. The key products and services to be delivered through this 5-year project (6/1/2025 - 5/31/2030) include: Characterization of the intermolecular energy landscapes for different types of macromolecules Simulation of macromolecular interactions...
The National Institute of General Medical Sciences (NIGMS) awarded a $2,041,875 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska. The project aims to utilize cutting-edge live-cell single molecule tracking, super-resolution microscopy, and CRISPR-Cas9 gene editing technologies to unravel the regulation of the Arp2/3 actin assembly complex and its role in cellular processes such as lamellipodial protrusion and cell migration. The project period runs from August 8, 2025 to July 31, 2029, with the goal of closing critical gaps in understanding how the mechanistic functions of the Arp2/3 complex relate to its effects on cellular physiology and disease. This research project leverages the University of Nebraska's expertise in cytoskeletal self-organization, cellular mechanisms, and advanced research methodologies to advance fundamental knowledge in the field of actin assembly and its biological implications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 8/6/25 |