Project Grant 2517636
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $288,550 Project Grant to the University of Rhode Island for research titled "EAGER: MECHANISM OF TOXIN ACTIVATION AND FUNCTION IN BACTERIA." The two-year award running from July 1, 2021 to June 30, 2023 is being conducted under the Biological Sciences program (CFDA 47.074). This grant aims to advance understanding of major problems confronting the nation by supporting basic research into the...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal project grant award to William Marsh Rice University provides $1,199,994 to study the role of bacterial deaminase toxins in cell physiology and microbial interactions. The project aims to characterize the substrate preference and structure of these DNA-targeting toxins, explore their biological roles, and develop tools to track toxin-mediated interactions in microbial communities. This research will enhance...
- The National Science Foundation awarded a $800,000 Project Grant to The University of Toledo to support research characterizing the stress response mechanisms of Vibrio bacteria through January 2025. Funded under the Biological Sciences program (CFDA 47.074), this award will further the program's goals of advancing biological science knowledge and understanding major challenges. Specifically, the University of Toledo researchers will characterize the Vibrio cholerae SIPA pathway and its role...
- This federal Project Grant award of $1,000,000.00 from the National Science Foundation's Biological Sciences program (CFDA 47.074) was provided to The Trustees of Princeton University to study "Quorum Sensing Across Scales and Between Domains". The project aims to investigate bacterial communication processes, known as quorum sensing, to better understand how bacteria can synchronize behavior and potentially control harmful pathogens or promote beneficial bacteria. Key objectives...
- This $1,500,004.00 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) to the J. David Gladstone Institutes supports research to investigate the mechanisms of a novel bacterial immune system called retrons. Retrons sense when a bacterial cell is infected by a virus (phage) and respond by killing the infected cell to protect the larger bacterial population. The key focus of this 3-year project (8/1/2025 - 7/31/2028) is to uncover the...
- This $213,180 Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) aims to establish a Transdisciplinary Training Program in Biomedical Sciences and Bioengineering (BSBE) at the University of Rhode Island (URI). The program will bring together predoctoral graduate students and faculty from diverse disciplines, including biology, human health, neuroscience, and biomedical engineering, to provide broad...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award, totaling $1,117,922.00, supports research to determine the mechanisms of bacterial tyrosine kinase activation and regulation. The Research Foundation of the City University of New York will utilize computational and experimental methods, including biochemical assays, NMR spectroscopy, and mass spectrometry, to investigate the activation of bacterial BY-kinases in both Gram-positive and Gram-negative...
- This $273,619 Project Grant was awarded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program to St. Jude Children's Research Hospital Inc. in Memphis, TN. The research project focuses on investigating the regulatory networks controlling bacterial dormancy and the environmental conditions driving this phenomenon, using Vibrio cholerae as a model system. The research aims to study the role of the transcription factor ToxR in bacterial dormancy, with...
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
- This Project Grant award of $440,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on two key research areas: Developing a quantitative understanding of the processes involved when contractile injection systems (e.g. phage tails, tailocins, Type VI secretion systems) breach bacterial cell envelopes. This knowledge will be applied to the design and retargeting of R-type pyocins...
This federal Project Grant award of $801,000.00 from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program supports research at the University of Rhode Island (URI) to investigate how bacteria use toxin-antitoxin systems to survive environmental stress, viral infection, and antibiotic exposure. The key objectives of the project are to: 1) identify how protein maintenance factors like chaperones and proteases regulate the activation of bacterial toxins by removing the neutralizing antitoxin, and 2) determine the role of ribosomes and ribosome-associated chaperones in this toxin activation process. The research aims to elucidate the mechanisms by which bacteria induce toxin-antitoxin systems to withstand environmental stresses. In addition to advancing scientific understanding, the project will provide research training for students to prepare them for careers in science and biomedical engineering. The award period is from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $801.0k | 7/28/25 |