Project Grant R01GM164444
- Federal Project Grant Award Summary The Johns Hopkins University received a $525,416 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. This award funds fundamental research investigating the structure and mechanisms of cellular processes essential to genome integrity, specifically focusing on two complementary research areas: (1) the regulation...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant totaling $414,709 under the Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on biomolecular condensates. The award, effective May 1, 2026 through February 28, 2031, supports the development and application of crosslinking mass spectrometry (XL-MS) methodology to map the structural architecture of...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $420,936 Project Grant effective April 1, 2026 through March 31, 2031 under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research investigating the mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis (CME), an essential cellular pathway for transporting extracellular...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $2.14 million Project Grant (CFDA 93.859: Biomedical Research and Research Training) effective September 1, 2025 through August 31, 2029 to conduct fundamental research on the molecular mechanisms of ribosome-mediated kinase signaling. The research project will investigate how ribosomes directly sense cellular stress and initiate downstream signaling pathways,...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant totaling $388,333 on March 16, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The five-year research initiative, scheduled for completion on February 28, 2031, focuses on characterizing flagellar motility in host-microbe symbiosis, with particular emphasis on understanding how flagellin proteins enable bacterial colonization...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $426,479 Project Grant effective September 1, 2025 through August 31, 2030 under the Biomedical Research and Research Training program (CFDA 93.859). The award funds development of statistical and computational methods to synthesize genomic and clinical data from biobanks, electronic health records, and clinical registries for precision risk stratification and...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant totaling $406,026 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). This grant supports the development of biophysical theory and mathematical models to advance understanding of biomolecular condensate dynamics—non-membrane-bound organelles formed through phase separation in cells. The research integrates...
- Federal Grant Award Summary The Johns Hopkins University received a $426,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with completion targeted for February 28, 2031. The project, "Probe Translation Regulation by Imaging Single Protein-mRNA Interaction in Live Cells," will deliver fundamental research findings and novel methodologies advancing the...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant of $458,950 under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through January 31, 2031. This award funds research to decipher the dynamics, structure, and function of cellular signaling networks that govern cell survival and response to environmental cues. The research employs a multidisciplinary approach...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $454,478 Project Grant (CFDA 93.859: Biomedical Research and Research Training) on September 10, 2025, to support research through August 31, 2030. The grant funds technology development to advance understanding of the glycan-protein interactome—the complex interactions between sugar structures (glycans) on cell surfaces and their protein binding partners. The research...
The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant totaling $325,665 (awarded June 1, 2026, with completion targeted for February 28, 2030) under the Biomedical Research and Research Training program (CFDA 93.859). This award funds mechanistic investigations into hydropersulfide (RSSH) donor-mediated rescue of deficient iron-sulfur (Fe-S) cluster biosynthesis in Friedreich's ataxia fibroblasts. The research addresses Fe-S cluster deficiencies underlying this neurodegenerative disorder caused by frataxin (FXN) protein deficiency, which impairs cluster formation, mitochondrial function, and increases oxidative stress. The research deliverables comprise two primary investigative aims: Aim 1 will analyze whether RSSH donors restore Fe-S cluster formation in FXN-deficient patient-derived skin fibroblasts, examining impacts on FXN levels, mitochondrial aconitase activity, ISCU2 persulfidation, and ferredoxin levels critical to cluster assembly. Aim 2 will elucidate the role of RSSH donors in improving mitochondrial biogenesis and related cellular functions. Research will be conducted at Johns Hopkins University's Baltimore, Maryland facility and is expected to generate fundamental scientific insights into potential therapeutic approaches for addressing Fe-S cluster biosynthesis deficiencies in Friedreich's ataxia.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $325.7k | 6/1/26 |