Project Grant R15AG101712
- Federal Grant Award Summary Boston University Medical Campus received a $327,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 5, 2025, with completion scheduled for August 31, 2027. The grant supports research exploring heterogeneity of cognitive trajectories in preclinical Alzheimer's disease through digital phenotyping methodologies. The project leverages multimodal data integration, combining traditional...
- Federal Grant Award Summary Brigham & Women's Hospital received a $3.69 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 15, 2025, with a completion date of September 14, 2029. The award funds development of specialized large language models (LLMs) designed to extract Alzheimer's disease and related dementias (ADRD)-relevant clinical phenotypes from electronic health records (EHRs). The project addresses a critical...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $470,000 Project Grant under the Aging Research program (CFDA 93.866) to Tufts University School of Medicine, with performance in Boston, Massachusetts. The award, effective February 1, 2026 through January 31, 2028, funds research to elucidate the interplay between Alzheimer's disease (AD) genetic variants using human induced pluripotent stem cell (iPSC)-derived brain cells. This two-year project addresses the genetic...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $445,130 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) beginning January 1, 2026 and concluding December 31, 2030. This award funds biomedical research directed toward elucidating the mechanisms by which MS4A (Membrane Spanning 4A) genes regulate neurodegeneration in Alzheimer's disease and related disorders, including frontotemporal dementia, multiple...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $1.34M Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded April 15, 2026, with completion targeted for March 31, 2031. The award supports research to develop advanced high-resolution magnetic resonance imaging (MRI) methodologies for noninvasively tracking cerebrospinal fluid (CSF) flow dynamics and amyloid-beta (AB) diffusion through perivascular spaces (PVS) in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $2,557,950 to The Feinstein Institutes for Medical Research under the Aging Research program (CFDA 93.866) on May 15, 2026, for research investigating the role of neurotoxic astrocytes in Alzheimer's disease (AD) pathogenesis. This R01 Project Grant, which extends through April 30, 2030, focuses on elucidating a novel molecular mechanism whereby extracellular cold-inducible RNA-binding protein (ECIRP) induces...
- Grant Award Summary The National Institute on Aging, under the Aging Research program (CFDA 93.866), awarded $4.59 million to the Regents of the University of California, San Francisco for a four-year project (September 5, 2025 through August 31, 2029) to develop and validate automated speech analysis technology for early detection of Alzheimer's disease (AD). The primary deliverable is an AD-specific speech profile utilizing machine learning algorithms to identify linguistic and acoustic...
- Federal Project Grant Summary The National Institute on Aging awarded $458,622 to the Research Foundation For Mental Hygiene, Inc. (operating as the New York State Psychiatric Institute) under the Aging Research program (CFDA 93.866) on March 1, 2026, with completion targeted for February 29, 2028. This project grant supports innovative research to elucidate the neuronal mechanisms and therapeutic potential of focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) as a novel treatment...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital a Project Grant totaling $335,880 under the Aging Research program (CFDA 93.866) on August 15, 2025, with a completion date of May 31, 2030. This grant supports research aimed at elucidating the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease (AD). The project addresses a critical gap in AD treatment by investigating why approximately 10-15% of individuals maintain...
The National Institute on Aging (part of the National Institutes of Health) awarded The MGH Institute of Health Professions, Inc. a Project Grant totaling $624,208 under the Aging Research program (CFDA 93.866) for the period June 1, 2026 through May 31, 2029. This research project investigates the relationship between cerebral microvascular hemodynamics and speech motor control in older adults at genetic risk for Alzheimer's disease (AD). The awardee will conduct biomedical research utilizing noninvasive magnetic resonance imaging (MRI) technology—specifically multi-delay arterial spin labeling (ASL) MRI—to measure cerebral blood flow and arterial transit time in brain regions supporting speech function. The research will generate scientific knowledge regarding mechanistic links between apolipoprotein E epsilon-4 (APOE-E4) genetic status, cerebrovascular physiology, and cognitive-motor function as potential early biomarkers for AD neurodegeneration. The project delivers research services and data collection activities in the established priority area of understanding Alzheimer's disease and related dementias through integrative biomedical research. By combining detailed acoustic and kinematic speech samples with advanced neuroimaging measures in a well-characterized cohort of older adults aged 60-80, the research aims to develop scalable, noninvasive behavioral and physiological indicators of preclinical neurodegeneration that could support early identification of individuals at elevated risk for AD.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $624.2k | 5/26/26 |