Project Grant R21AG098894
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $852,273 through the Aging Research program (CFDA 93.866) to conduct a comprehensive genetic mapping study of RNA modifications in the aging human brain and their association with Alzheimer's disease (AD). This project grant, initiated September 1, 2025, with completion targeted for May 31, 2030, will deliver a multi-faceted research effort examining how genetic...
- Federal Grant Award Summary Harvard Medical School received a $125,901 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of May 31, 2027. The grant supports research investigating cell-type-specific dysregulation and genetic control of alternative polyadenylation (APA) in neurodegenerative disease, specifically Alzheimer's disease and Parkinson's disease. The research delivers novel...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $1,851,569 under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. This research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the biological mechanisms linking early brain development to late-life Alzheimer's disease (AD) pathology. The project aims to empirically...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $804,450 under the Aging Research program (CFDA 93.866) effective June 1, 2025, through March 31, 2030. This award supports scientific research investigating the mechanisms by which Apolipoprotein E4 (APOE4), a major genetic risk factor for Alzheimer's disease (AD), drives pathogenesis through neuronal dysfunction and network hyperexcitability. The research will...
- Federal Grant Award Summary New York University School of Medicine received a $642,063 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 15, 2026, with completion targeted for December 31, 2030. The award supports a collaborative research investigation examining gabaergic microcircuits in the hippocampal CA1 region to identify cellular targets and neuromodulatory mechanisms for early-stage Alzheimer's disease (AD)...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $412,500 Project Grant to the University of South Florida (USF) under the Aging Research program (CFDA 93.866) for a two-year research initiative running from June 1, 2025, through May 31, 2027. This grant funds scientific research aimed at identifying novel biomarkers for early diagnosis and prognosis prediction of Alzheimer's disease (AD), a neurodegenerative condition affecting 5.5 million Americans. The project...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $509,413 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025 through May 31, 2030. This award funds scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), with the primary deliverable being novel research findings and analysis concerning how adenosine methylation...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a $480,710 Project Grant effective September 5, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports scientific investigation into a novel vascular signaling pathway that regulates neuronal survival in neurodegenerative diseases, specifically Alzheimer's disease and related dementias (ADRD), amyotrophic lateral sclerosis (ALS), and...
- Federal Grant Award Summary The National Institute on Aging awarded University of California, Irvine a $773,816 Project Grant under the Aging Research program (CFDA 93.866) on June 1, 2025, with a completion date of March 31, 2030. This award funds a multi-investigator research initiative investigating cell-type-specific and spatial proteogenomics analysis of aberrant RNA splicing and misfolded proteins in Alzheimer's-related tauopathies. The research team will generate single-cell spatial...
- Federal Project Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a $441,612 project grant to the Trustees of Boston University (Boston University Medical Campus) effective May 15, 2025, with a completion date of January 31, 2030. This research initiative investigates the relationship between Life's Essential 8 (LE8)—a quantified set of modifiable lifestyle and clinical risk factors—and digital cognitive markers in predicting...
The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated heritability of approximately 70% and exists in both monogenic and polygenic forms, this research leverages induced pluripotent stem cell (iPSC) technology to generate human brain cells for studying how different genetic variants interact and contribute to disease pathogenesis. The project delivers scientific research outputs and analysis focused on understanding the interplay between AD genetic variants through cellular and molecular investigations using human iPSC-derived brain cells. This work directly supports the NIA's mission to advance biomedical research directed toward greater understanding of aging processes and age-related diseases, with particular emphasis on preventing and treating Alzheimer's disease and related dementias. The two-year project period enables comprehensive investigation into genetic mechanisms that may inform future therapeutic strategies for this leading cause of dementia.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $470.0k | 1/29/26 |