Project Grant R21AG098632
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $529,744 Project Grant on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanisms driving Alzheimer's disease progression through the entorhinal cortex-hippocampal circuit. The research will utilize in vivo two-photon microscopy and targeted neuronal manipulation techniques to examine three interconnected factors hypothesized...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $2,957,210 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025, under the Aging Research program (CFDA 93.866). The grant funds a comprehensive four-year research initiative (completion by August 31, 2029) to decipher the functional role of CD44 astrocytes in Alzheimer's disease (AD) pathology. The research program will deliver...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $852,273 under the Aging Research program (CFDA 93.866) effective September 1, 2025, through May 31, 2030. This Project Grant supports a comprehensive research initiative investigating the role of RNA modifications in Alzheimer's disease (AD) pathogenesis through an integrated approach combining genetics, multi-omics analysis, and functional validation....
- Federal Grant Award Summary The University of Virginia received a $1.52M Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded May 15, 2025, with a completion date of February 28, 2030. This award supports the development and deployment of magnetic resonance (MR) image-guided focused ultrasound (FUS) technology combined with microbubbles to selectively deliver SHIP-1 neutralizing therapies across the blood-brain barrier to microglial cells in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $3.23 million through its Aging Research program (CFDA 93.866) to the University of Kansas Center for Research Inc. for a project grant extending from September 30, 2025, through August 31, 2029. The award supports investigative research examining the interplay between neuronal activity, synaptic dysfunction, and mitochondrial abnormalities in Alzheimer's disease. The research will utilize mouse models of...
- Federal Grant Award Summary The National Institute on Aging awarded The Trustees of Columbia University in the City of New York a $3.64M Project Grant under the Aging Research program (CFDA 93.866) effective August 5, 2025, through July 31, 2030. The award funds the FUNGEN-XQTL initiative, which delivers a comprehensive multi-omics research resource and analytical framework for identifying causal genes, cell types, and molecular mechanisms underlying Alzheimer's disease. The project generates...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.9 million Project Grant under the Aging Research program (CFDA 93.866) to develop a Multi-Organ AI-Derived Endophenotype (MAE) framework for personalized assessment of Alzheimer's disease and related dementia susceptibility. The grant, effective August 1, 2025 through July 31, 2029, supports the creation of computational diagnostic and prognostic tools by consolidating and...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded The Washington University a $1.85 million Project Grant under the Aging Research program (CFDA 93.866) effective June 1, 2025, with a project completion date of March 31, 2030. This research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the relationship between early brain development and late-life Alzheimer's disease (AD) pathology. The project examines whether...
- Federal Grant Award Summary The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai a $2.13 million Project Grant under the Aging Research program (CFDA 93.866) to develop and validate engineered adeno-associated viruses (AAVs) for targeted gene knockdown in Alzheimer's disease-vulnerable neurons. The two-year project, initiated August 1, 2025 and concluding July 31, 2027, focuses on creating AAV constructs containing neuron-specific enhancers and follicle-stimulating...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $18.3 million under the Aging Research program (CFDA 93.866) for a project period spanning February 1, 2026, through January 31, 2030. This Project Grant supports comprehensive research investigating the association between metal exposures and Alzheimer's disease (AD) and AD-related dementia (ADRD) risk in diverse U.S. populations. The research leverages...
Federal Project Grant Award Summary The National Institute on Aging awarded $458,622 to the Research Foundation For Mental Hygiene, Inc. (through its New York State Psychiatric Institute division) under the Aging Research program (CFDA 93.866) beginning March 1, 2026, with a completion date of February 29, 2028. This project grant funds innovative research to identify the impact of focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) on brain-wide memory traces in Alzheimer's disease and related dementias (ADRD). The research aims to elucidate the molecular and neuronal mechanisms by which FUS-BBBO can modulate neural ensembles to improve contextual memory discrimination, a cognitive function impaired in AD and ADRD patients. The deliverables from this research initiative include scientific findings on how FUS-BBBO and focused ultrasound neuromodulation (FUS-NM) influence neural ensembles mediating memory formation and discrimination. The project leverages advanced research methodologies including behavioral assays, single-nucleus RNA-sequencing (snRNA-seq), brain-wide immunolabeling, and network modeling on transgenic mouse models to generate novel insights into potential therapeutic approaches for cognitive loss in aging populations. This research directly supports the National Institute on Aging's mission to develop preventive and treatment strategies for Alzheimer's disease and related dementias through biomedical research conducted at a nonprofit research institution affiliated with Columbia University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.6k | 2/20/26 |