Project Grant R03TR005428

Award Date 7/1/24
Completion Date 6/30/25
Dollars Obligated $177K
Federal Grant Program
93.350
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98195, USA
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The National Institutes of Health, through the National Center for Advancing Translational Sciences (CFDA 93.350), awarded a $163,750 Project Grant to The Johns Hopkins University to develop a human keratinocyte model and test the efficacy of lentiviral-mediated SPCA1 delivery for treating Hailey Hailey disease. The grant supports two specific aims: 1) clarifying the disease mechanism underlying the rare autosomal dominant skin disorder caused by ATP2C1 gene mutations, and 2) evaluating the...
This Project Grant award of $161,922 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at The Johns Hopkins University to investigate the role of gamma secretase (GS) activity and nicastrin (NCSTN) regulation in hidradenitis suppurativa (HS), a chronic inflammatory skin condition. The research aims to define the enzymatic activity of GS and regulation of NCSTN expression in HS fibroblasts, as well as...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $343,904 to The Regents of the University of California, San Francisco to investigate transcriptional abnormalities in skin-resident T cells as potential biomarkers for atopic dermatitis in Asian and Hispanic genetic backgrounds. The research aims to validate an abnormal atopic T...
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This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $176,500.00 to the University of Washington for the period of July 1, 2024 to June 30, 2025. The goal of the project is to delineate the pathogenic effects of ATP2C1 loss-of-function in human keratinocytes and organotypic epidermis to identify therapeutic strategies for Hailey-Hailey Disease (HHD), a rare skin blistering disorder. The research aims to determine how SPCA1 deficiency compromises keratinocyte cell-cell adhesion and identify pathways that could restore epidermal integrity in an HHD model. The work leverages cellular and tissue models developed using CRISPR/Cas9 to ablate ATP2C1 in human keratinocytes. The findings are expected to provide a platform for validating druggable targets and advancing lead compounds for clinical trials to improve skin integrity in HHD patients.

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