Project Grant R01AR083385

Award Date 9/2/24
Completion Date 7/31/29
Dollars Obligated $466K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Miami, FL 33136, USA
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This federal Project Grant award of $466,198, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the role of cortisol synthesis in the pathogenesis of intradermal tunnels associated with hidradenitis suppurativa (HS), a common and debilitating inflammatory skin disease.

The key products and services to be delivered under this grant include:

  • Utilizing tissue samples, primary cell cultures, and 3D organotypic HS skin models to determine the role of cortisol synthesis in HS tunnel formation and perpetual inflammation
  • Testing whether targeting cortisol synthesis can restore function and activation of HS tunnel keratinocytes and fibroblasts
  • Investigating how genomic and non-genomic glucocorticoid receptor signaling contributes to the pathophysiology of HS tunnels and HS in general The goal is to gain mechanistic insights that could lead to the development of novel, tunnel-targeted therapeutics to modulate cortisol synthesis and ameliorate HS disease progression.

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