This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify genetic abnormalities in skin T cells that contribute to atopic dermatitis in Asian and Hispanic populations. The total award amount is $343,904, with a project period from Sep 20, 2024 to Aug 31, 2025. The award recipient is The Regents of the University of California, San Francisco, a leading academic medical center and research institution. The research aims to validate an abnormal atopic T cell signature in diverse genetic backgrounds and experimentally test if specific genes in this signature can induce a Th2 cell identity, using advanced techniques like CRISPR/Cas9 gene activation and single-cell spatial transcriptomics. The expected outcome is a population- and mechanism-validated set of genetic abnormalities that characterize atopic dermatitis in Asian and Hispanic patients, which could guide more personalized treatment approaches and help reduce the substantial burden of this disease in non-European populations.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $343.9k | 9/20/24 |