This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $176,500.00 to the University of Washington for the period of July 1, 2024 to June 30, 2025. The goal of the project is to delineate the pathogenic effects of ATP2C1 loss-of-function in human keratinocytes and organotypic epidermis to identify therapeutic strategies for Hailey-Hailey Disease (HHD), a rare skin blistering disorder. The research aims to determine how SPCA1 deficiency...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the role of gamma secretase (GS) activity and regulation of the NCSTN protein in hidradenitis suppurativa (HS), a chronic inflammatory skin disease. The $161,922 award to The Johns Hopkins University will fund studies to characterize GS enzymatic activity and NCSTN expression in HS patient...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $359,879 to the University of North Carolina at Chapel Hill to conduct research on the genetic basis of hidradenitis suppurativa (HS), a chronic inflammatory skin disease. The research aims to build upon previous genome-wide association studies to identify additional genetic risk...
This $718,693 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support a collaborative research project between Henry Ford Health and Michigan State University Health Sciences to conduct whole-genome sequencing analysis of Hidradenitis Suppurativa (HS). The key objectives are to: 1) Perform whole-genome sequencing analysis to identify...
This Project Grant award from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program provides $3,674,785.00 to The Johns Hopkins University to conduct research on gene therapy applications for polycystic kidney disease. The award period runs from June 1, 2025 to May 31, 2029. As a leading academic research institution, The Johns Hopkins University has a robust track record of supporting critical federal research initiatives across biomedical,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,279,005 to The Johns Hopkins University to conduct research on hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) transcriptional silencing, with a focus on comparing HBV mono-infection and HBV/HIV co-infection. The 5-year project aims to uncover the mechanisms underlying cccDNA transcriptional...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on developing a potentially curative gene editing therapy for latent Herpes Simplex Virus Type 2 (HSV-2) infection. The $303,731 award to Caladan Therapeutics, Inc. aims to select and validate a lead meganuclease variant that can specifically target and eliminate HSV-2 from latently infected ganglionic neurons, which...
This federal Project Grant award of $466,198, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the role of cortisol synthesis in the pathogenesis of intradermal tunnels associated with hidradenitis suppurativa (HS), a common and debilitating inflammatory skin disease. The key products and services to be delivered under this grant include:...
This $881,878 federal Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award aims to study the cross-talk between skin-resident T-cells (CD8 T resident memory cells) and keratinocytes, the primary target of herpes simplex virus (HSV) infection, to understand how this interaction influences HSV recurrence. The research will utilize advanced techniques such as single-cell RNA...
This Project Grant award of $649,391, awarded on May 12, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research to enhance healing after injury. The research, conducted by The Johns Hopkins University, aims to define the mechanisms that restrain healing in epithelial tissues like skin and gut, with the goal of developing new therapies to improve regeneration following diverse injuries or infections. The work is funded through the NIAMS...