This federal Project Grant award of $160,000.00 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by Baylor College of Medicine to elucidate the morphogenetic and molecular mechanisms by which the genes RERE and SPEN contribute to the development of congenital heart defects associated with 1p36 deletion syndrome. The research aims to determine how SPEN deficiency triggers morphogenetic changes in the developing atrioventricular (AV) canal that lead to ventricular septal defects, and to investigate the molecular mechanisms by which SPEN and RERE interact to regulate the expression of key cardiac developmental genes like GATA4, BMP6, and BMP7. The innovative mouse models developed through this grant will provide a platform to test potential therapeutic and preventative interventions not only for 1p36 deletion syndrome, but also for a broader population at risk of ventricular septal defects.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $160.0k | 7/19/24 |