This $619,304.36 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to develop and apply tools to precisely modulate the dosage of craniofacial transcription factors in cranial neural crest cells and assess the molecular, cellular, and morphological effects. The initial focus is on understanding the rules governing regulatory element and gene sensitivity to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $452,681 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of California, San Francisco (UCSF) to investigate the role of the ESCRT (Endosomal Sorting Complexes Required for Transport) machinery in regulating craniofacial morphogenesis. The 5-year project aims to determine the tissue-specific contributions of the ESCRT complex to mammalian craniofacial development, characterize how...
This Project Grant award, totaling $142,996, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports a two-year research project led by the University Corporation at Monterey Bay to investigate how migrating cells can influence the development of their substrate, specifically the trunk visceral mesoderm (TVM), during collective cell migration.
The objective...
The National Institute of Child Health and Human Development (NICHD) awarded a $623,342.22 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Regents of the University of California at Riverside (UC Riverside). The grant, valid from August 1, 2024 to July 31, 2027, will support research to determine the general principles and causal mechanisms underlying subcellular RNA localization, and the physiological implications during development...
This $378,123 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports a research project to identify and test mechanisms that establish the transcriptional regulatory potency of early embryos. The key products and services to be provided include:
Utilizing genomic methods such as Pro-Seq, DREG, and OMNI-ATAC to identify transcriptionally active...
This Project Grant award, valued at $455,939, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports research to investigate the molecular and cellular mechanisms underlying craniofacial malformations associated with dosage-dependent defects in the FGF8 signaling pathway.
Key objectives of the research project include: 1) exploring how FGF8 dosage impacts the development and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research on the role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology, specifically related to Mowat-Wilson Syndrome. The $521,209.45 award will fund a 3-year project to examine how ZEB2 regulates TGF-beta signaling during normal neural crest development and how...
This $178,848 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to elucidate the molecular mechanisms underlying cleft lip formation. The principal investigator, Dr. Teng, will leverage newly developed mouse models and live imaging approaches to investigate how the p120-catenin protein regulates the cellular behaviors and forces driving lip fusion during...
This $1,204,928 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, is focused on decoding the mechanism of pathogenic enhancer mutations in congenital limb disorders.
The project aims to utilize transgenic mouse models and gene editing techniques to characterize how rare, gain-of-function enhancer variants in the ZRS limb enhancer of the Sonic Hedgehog (SHH) gene result in...
This federal Project Grant award of $622,608.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to study the genomic and developmental mechanisms underlying frontonasal dysplasia, a congenital craniofacial disorder. The research, led by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to investigate how structural variations, such as deletions and duplications,...