The federal Project Grant award R03HD113887, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of the ZFHX4 gene in lung mesenchyme development and its potential implications for understanding the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia (CDH). The $164,990 award, with a performance period from August 1, 2024 to...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,057,973 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to The Johns Hopkins University to conduct research on modeling fetal lung development in congenital diaphragmatic hernia (CDH). The research aims to investigate the role of the YAP/TAZ mechanosensing pathway in CDH lung hypoplasia using mouse models, human lung organoids, and large animal fetal models. The research teams led by Shaun Kunisaki, Jason...
The National Institute of Child Health and Human Development (NICHD) awarded The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), a $167,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to study the impact of epigenetic regulation on lung stem cells in congenital lung diseases. The project aims to determine how genetic variants and pharmaceutical interventions affect the differentiation and self-renewal of...
This $161,500 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant is intended to establish basic science-clinical collaborations to understand the molecular mechanisms of heterotaxy, a severe form of congenital heart disease that affects 3-4% of patients with congenital heart defects. The funding will support research at the University of Virginia to...
This federal Project Grant award of $1,808,868 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to understand the pathophysiological mechanisms driving ciliopathy-associated structural birth defects. The University of Alabama at Birmingham (UAB) will identify and characterize genetic variants of interest from patient and variant repositories,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, will provide $267,000 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) from August 1, 2025 to July 31, 2027. The goal of this project is to identify shared genetic mechanisms that disrupt both heart and brain development in individuals with congenital heart disease (CHD) and neurodevelopmental delays (NDD). The...
This federal Project Grant award of $249,000 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to identify new therapeutics and understand molecular mechanisms for Congenital Disorders of Glycosylation (CDGs). The key objectives are to: 1) Determine the mechanisms of modifier genes that can rescue a DPAGT1-CDG cell model, 2) Conduct a drug repurposing screen in a DPAGT1-CDG...
This Project Grant award of $311,000 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund the development of comprehensive de novo variant (DNV) callsets for the Gabriella Miller Kids First Pediatric Research Program's birth defects dataset. The key products to be delivered under this 2-year award include: 1) Identification of new genes involved in birth defects through the...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to assess variants of uncertain significance in the intellectual disability gene ANKRD17. The $265,500 award to The Children's Hospital Corporation (dba Boston Children's Hospital) will fund an efficient and innovative strategy to evaluate variants in ANKRD17, a gene that causes...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $844,386 to support research on the genetic landscape of childhood interstitial and diffuse lung diseases (CHILD). The key objectives are to: 1) Define molecular profiles of 300 CHILD lung biopsy samples to identify patient clusters with similar underlying causes, 2) Analyze whole exome sequence data from 400 children with...