The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded The University of Texas Southwestern Medical Center (UT Southwestern) a $802,762 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to define the transcription factors and gene regulatory networks underlying human cardiac development, characterize genetic variants regulating cardiac gene programs, and assess the impact of coding and non-coding variants on molecular and cellular phenotypes in congenital heart disease. This research will utilize experimentally-derived gene regulatory networks to interpret the function of known and novel genetic variants. The goal is to expand understanding of how genetic variation affects transcription factor activity, cardiac gene regulatory networks, and lineage specification, which will enable better functional interpretation of variants in congenital heart disease patients. The project has a period of performance from February 1, 2025 to December 31, 2028.
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