Project Grant R03DE036051
- The National Institute of Dental and Craniofacial Research awarded Duke University $444,125 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate central nervous system and autonomic correlates of temporomandibular disorder pain. The research characterizes how altered brainstem circuit activity and brain glymphatic flow relate to autonomic dysfunction in patients with chronic painful temporomandibular disorder (TMD). The project measures...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $310,295 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on September 11, 2025, with a completion date of September 10, 2027. This research initiative aims to identify distinct subgroups of adolescents with chronic temporomandibular disorder (TMD) pain based on clinically relevant features...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $111,828 on January 8, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund fellowship training in neural circuit research related to temporomandibular joint disorder. The project investigates central nervous system dysfunction underlying temporomandibular joint disorder pathophysiology, specifically testing the hypothesis that alterations in amygdala-brainstem circuitry...
- The National Institute of Dental and Craniofacial Research awarded the University of North Carolina at Chapel Hill $682,398 under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 1, 2026. The recipient will develop a predictive algorithm to identify individuals at high risk of developing long COVID based on high-resolution phenotyping of the immunologic, microbial, proteomic, and metabolomic landscape of the oral cavity during and after SARS-CoV-2 infection. The project...
- The National Institute of Dental and Craniofacial Research awarded the University of Pittsburgh a cooperative agreement worth $8,154,330 on September 9, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish the Collaborative for Research to Advance TMD Evidence (CREATE), a multi-site research initiative addressing temporomandibular disorders through integrated clinical and preclinical research. CREATE operates three functional cores plus a central longitudinal...
- The National Institutes of Health Office of the Director awarded the University of Southern California a cooperative agreement worth $958,699 on September 11, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds the Broader Evaluation of TMD Treatment Efficacy and Response (BETTER TMD) project, which develops machine learning algorithms to predict individualized treatment outcomes for temporomandibular disorder and orofacial pain patients. The project...
- This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
- The National Institute of Dental and Craniofacial Research awarded the University of Washington $623,593 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of P75 neurotrophin receptor (P75NTR) in temporomandibular joint (TMJ) cartilage homeostasis and degenerative disease. The research defines cellular and molecular mechanisms regulating TMJ cartilage health and degeneration, with the goal of developing novel therapeutic strategies...
- The National Institute of Dental and Craniofacial Research awarded The University of Texas Health Science Center at San Antonio $433,125 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neuronal-glial coupling mechanisms in temporomandibular joint pain. The project examines the role of connexin 43, a gap junction protein expressed in satellite glial cells, in modulating trigeminal ganglion neuron-glia communication and pain processing in...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Children's Hospital of Philadelphia Research Institute a $507,006 Project Grant on August 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of hyaluronan in YAP (Yes-associated protein) signaling on temporomandibular joint (TMJ) health and pathology. The research will be conducted over a two-year period through July 31, 2027, and focuses...
The National Institute of Dental and Craniofacial Research awarded $310,274 to the University of North Carolina at Chapel Hill on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds a multidimensional phenotyping study characterizing the molecular, sensory, and psychosocial factors underlying comorbid temporomandibular disorder and migraine in adolescents. The project recruits 140 youth aged 10 to 17 years with TMD myalgia, stratified by the presence or absence of migraine, to establish an integrated dataset encompassing salivary biomarkers, quantitative sensory testing, and psychosocial profiling. The research applies machine learning to stratify patients based on integrated biological, sensory, and psychosocial risk signatures, with the goal of advancing individualized pain management for youth with comorbid TMD and migraine. Preliminary data show that nearly 60 percent of adolescents with painful TMD report comorbid headache, characterizing a subgroup with elevated pain intensity, greater functional impairment, and increased psychological distress. The study addresses a critical gap: no pediatric studies have integrated molecular, sensory, and psychosocial data to phenotype youth with comorbid TMD and migraine, which hinders early identification of high-risk subgroups and personalized treatment during a key developmental window. Work is performed in Chapel Hill, North Carolina. The period of performance runs from August 28, 2026, through August 27, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $310.3k | 8/31/26 |