This $222,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research at The Children's Hospital of Philadelphia (CHOP) to investigate the pathogenic mechanisms of temporomandibular joint (TMJ) osteophyte formation. The key objectives are to test whether conditional ablation of the gene EXT1, which is involved in heparan sulfate synthesis, causes osteophyte formation...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $738,929 to The Trustees of Columbia University in the City of New York to develop and validate a patient-specific TMJ-on-a-chip (TMJOC) model. The TMJOC will be used to investigate multi-tissue crosstalk regulating temporomandibular joint (TMJ) disc injury and healing under inflammation and pathophysiological...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $143,285 project grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Southern California (USC). The project aims to identify the cellular origins of cartilage regeneration in the zebrafish jaw joint, which could inform future treatments for temporomandibular joint osteoarthritis (TMJ OA) in humans. The grant will fund research to optimize a transgenic cartilage ablation...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $385,161 project grant on Sep 5, 2024 under the Oral Diseases and Disorders Research (CFDA 93.121) program to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) Division. This grant aims to investigate the role of p21 positive senescent cells in obesity, aging, and trauma-induced temporomandibular joint (TMJ) degeneration, a painful and debilitating joint disease...
The federal Cooperative Agreement award UH3DE032204 was granted by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The $1,660,925.63 award supports a project at Thomas Jefferson University's Sidney Kimmel Medical College to utilize single-cell RNA sequencing to identify and classify cell populations and gene expression in temporomandibular joint (TMJ) synovial fluid from healthy and symptomatic TMJ...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $1,013,625 to the University of Pittsburgh to investigate the use of a porcine small intestine submucosa (SIS) scaffold for temporomandibular joint (TMJ) disc regeneration. The goal is to develop a safe and effective treatment for TMJ disc replacement, addressing the lack of FDA-approved options that leads to joint...
This federal Cooperative Agreement award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research grant program (CFDA 93.121), aims to conduct multi-omic investigations of temporomandibular joint (TMJ) disorders. The $587,428 award will support a two-phase project at the University of California, Los Angeles (UCLA) to: 1) develop protocols and infrastructure for data management, subject recruitment, and sample collection; and 2)...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $299,782 to develop and validate a novel Jaw Metabolic Stressor (JMS) task. The JMS task is designed to evoke targeted levels of jaw pain and fatigue in both chronic temporomandibular disorder (TMD) pain patients and healthy controls, in order to investigate the peripheral and central neural mechanisms...
This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan Office of Research and Sponsored Projects to establish the Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR). The goal of the award is to transform the treatment of temporomandibular disorders (TMDs) through the translation of clinically-relevant innovations. The...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research on the role of hyaluronan (HA) in temporomandibular joint (TMJ) health and pathology. The $507,006 award, with a project period from August 1, 2025 to July 31, 2027, will be administered by The Children's Hospital of Philadelphia (CHOP).
The key objectives of this research project are to investigate the regulatory mechanisms of HA synthesis and processing in healthy and osteoarthritic TMJs, assess the impact of HA depletion on TMJ cell function, and evaluate whether YAP signaling inhibition can prevent or inhibit TMJ osteoarthritis. The research will utilize a range of techniques, including single-cell RNA sequencing, conditional ablation studies, and evaluation of mechanical properties and lubrication. The findings from this project are expected to provide novel insights into the roles of HA in TMJ biology and disease, potentially leading to the development of new treatment options for TMJ and other joint-related musculoskeletal conditions.