The National Institute on Aging (NIA), through the Aging Research Federal Grant Program (CFDA 93.866), awarded a $1,562,788 Project Grant (R01AG085469) to the University of Florida to comprehensively profile the blood (serum) and brain N-glycome in relation to Alzheimer's disease (AD). The project will leverage the large collection of biospecimens and data from two community-based prospective cohorts to understand the mechanisms through which aberrant N-glycosylation affects AD and identify...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease pathogenesis interferes with synaptic autophagy, and evaluate if optimizing synaptic autophagy can be neuroprotective in an Alzheimer's mouse model. The $628,000 award to Rutgers, The State University of New Jersey, will utilize primary hippocampal cell cultures and mouse models to study the disruption of autophagic processing of synaptic proteins in...
This $2,085,904 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of glycated tau and advanced glycation end products (AGEs) in the pathology, neurotoxicity, aggregation, and neuroinflammation associated with Alzheimer's disease (AD). The 5-year project, commencing on May 1, 2024, will be conducted by the University of Colorado and aims to provide molecular-level insights into the connections between type 2...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rutgers, The State University will support a research project examining the role of the microtubule network in a mouse model of Alzheimer's disease. The $447,354 award, running from August 1, 2024 through April 30, 2026, will investigate how changes in microtubule stability and the microtubule-associated protein stathmin affect synaptic function, plasticity, and memory in a tau-related...
This $326,797 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to use proteomic analyses to identify proteins and protein networks associated with mild cognitive impairment in individuals with type 2 diabetes. The project's primary goal is to illuminate the underlying molecular mechanisms driving cognitive impairment in this population, with the potential to identify biomarkers for risk stratification and protein targets for therapeutic...
The National Institute on Aging (NIA) awarded a $772,435 Project Grant under the Aging Research program (CFDA 93.866) to The University of Iowa. The 5-year grant, with a period of performance from Sep 30, 2024 to May 31, 2029, will fund research to investigate how disruptions in glycolysis, a key metabolic process, contribute to neurodegeneration in Alzheimer's disease (AD) rodent models. The project aims to determine if improving glycolysis can mitigate neurodegeneration in AD. Researchers...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports a comprehensive investigation of protein kinase signaling networks involved in the progression of Alzheimer's dementia (AD). The $788,021 award, effective September 15, 2024 through May 31, 2029, enables a multi-omics, hypothesis-generating series of experiments conducted by a team of established investigators at the University of Toledo Health Science Campus...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to generate a comprehensive atlas of neurovascular protein lifetimes in health, aging, and a tauopathy-based model of Alzheimer's disease. The $437,875 award provides funding to researchers at the University of California, San Diego to employ stable isotope labeling in mammals (SILAM) and mass spectrometry-based proteomics to quantify changes in neurovascular protein lifetimes during...
This $2,261,852 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Pennsylvania State University (Penn State) will support the development of novel statistical tools and computational models to disentangle subtle cognitive decline from learning effects. The project aims to create digital cognitive markers that can improve detection of early-stage Alzheimer's disease and related dementias (ADRD) and enable better risk prediction. Key...
This federal Project Grant award (R03AG087475) for $295,000 from the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program aims to develop biotherapeutic nanogels for the treatment of Alzheimer's disease (AD). The project utilizes patented autofluorescent biopolymeric nanogels with anti-viral properties, biodegradability, and cellular biocompatibility to target key AD biomarkers, including amyloid-beta, neurofibrillary tangles, and inflammatory markers. The goals...