This $15,046,454 project grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at the University of California, San Diego to improve understanding of proteomic changes preceding Alzheimer's disease and related dementias. The research will analyze longitudinal plasma samples from 2,836 women in the Women's Health Initiative Memory Study cohort using the Somamscan proteomics platform to identify novel proteomic biomarkers, signatures, and biological pathways for mild cognitive impairment, Alzheimer's disease and related dementias, as well as cognitively healthy longevity. Subawards of $15,337, $31,019, $1,993,774 and $135,406 have been issued to Wake Forest University Health Sciences, Kaiser Foundation Research Institute, Beth Israel Deaconess Medical Center, and Fred Hutchinson Cancer Center respectively to support proteomics analyses, statistical modeling, and specimen processing work under the project. Results are intended to advance knowledge of heterogeneous mechanisms in aging and cognitive impairment and identify risk and protective proteomic factors.
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