This $239,758 Project Grant, awarded by the National Institute on Aging under the Aging Research federal grant program (CFDA 93.866), will fund the development of a microphysiological system that models the interactions between the brain, meninges, and lymphatic system in both healthy and Alzheimer's disease conditions. The research team, led by Virginia Polytechnic Institute & State University, will integrate three tissue-engineered models (of the human brain, lymph node, and meninges) into...
The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
This $640,906 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to elucidate the role of cerebrovascular disease (CVD) processes in contributing to cognitive decline and Alzheimer's disease (AD) pathology. The project aims to utilize advanced neuroimaging techniques to characterize specific CVD factors, such as vascular stiffness and neurovascular flow dynamics, and evaluate their impact on brain tissue integrity and cognition in...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to better understand the role of microglia, the brain's immune cells, in the progression of Alzheimer's disease (AD). The University of Washington is the prime awardee and will leverage novel explainable AI techniques and human-induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes occurring early in AD. Specific objectives include using AI to identify...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,017,307 to the University of Illinois to conduct research on brain stiffness as a predictor of chronic subdural hematoma (CSDH) characteristics and tissue re-expansion. The project will leverage magnetic resonance elastography (MRE) to quantitatively measure brain mechanical properties and correlate these with CSDH size, density, and brain tissue re-expansion after treatment. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $2,317,887 will be used by Indiana University Indianapolis to map paravascular cerebrospinal fluid (PCSF) signatures associated with healthy aging, aging with hypertension, and Alzheimer's disease (AD). The researchers will leverage dynamic diffusion-weighted imaging, a novel neuroimaging technique, to quantify PCSF dynamics and volume near major arteries - a key component of the glymphatic...
The National Institute on Aging (NIA) awarded a $441,612 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Trustees of Boston University, doing business as Boston University Medical Campus. The grant, effective May 15, 2025 through January 31, 2030, will leverage the Framingham Heart Study's digital cognitive data to evaluate the relationship between the Life's Essential 8 metrics for modifiable risk factors and digital cognitive markers for early detection of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $4,692,540 to Northwestern University to develop advanced MRI techniques for directly assessing cerebral microvascular pulsatility, a key indicator of cerebral small vessel disease (CSVD). The research aims to create clinically applicable MRI tools that can improve understanding of how microvascular dysfunction contributes to CSVD and related conditions like Alzheimer's disease and vascular...
This federal Project Grant award, valued at $205,619 and awarded by the National Institute on Aging under CFDA 93.866 (Aging Research), will support research to map the landscape of the aged human brain in order to develop neurodegenerative disease models. The grant recipient, the University of Washington, will apply explainable artificial intelligence (XAI) methods to human brain data sets to identify molecular drivers of brain aging. The researchers will then manipulate these aging-related...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,193,370.00 to Neuroscope Inc. to develop a computational toolset for automated mapping and quantification of perivascular spaces (PVS) from magnetic resonance imaging (MRI) data. The goal is to create a non-invasive diagnostic aid for Alzheimer's disease, as changes in PVS integrity are an important clinical feature of the disease. The project will build the IT infrastructure required to...