Project Grant RF1AG083762
- Federal Grant Award Summary The National Institute on Aging (NIA) under its Aging Research program (CFDA 93.866) awarded Indiana University a $1.23 million Project Grant effective February 1, 2026, through January 31, 2031, to develop artificial intelligence (AI)-driven drug discovery pipelines targeting Alzheimer's disease and related dementias (AD/ADRD). The research will focus on three primary deliverables: (1) creation of an accelerated docking-based virtual screening pipeline...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $670,530 Project Grant effective April 15, 2026, through March 31, 2031, under the Aging Research program (CFDA 93.866). The award supports research to develop and optimize advanced high-resolution magnetic resonance imaging (MRI) methods for noninvasively tracking cerebrospinal fluid (CSF) flow and amyloid-beta (Aβ) dynamics through perivascular spaces (PVS) in the brain. The research aims...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $607,706 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded March 1, 2026, with a completion date of January 31, 2031. This award funds a five-year research project investigating short-term practice effects (STPE) as biomarkers for subjective cognitive decline (SCD), a preclinical manifestation of Alzheimer's disease. The research will examine whether...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- Federal Grant Award Summary The National Institute on Aging awarded University of Maryland, Baltimore a $589,154 Project Grant under the Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This research project develops and validates a normalized cerebrovascular reactivity (NCVR) magnetic resonance imaging technique to improve detection of vascular contributions to cognitive impairment in small-vessel disease patients. The project addresses a critical gap...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis $3,126,515 on August 15, 2025, under the Aging Research program (CFDA 93.866) to support research investigating a novel inter-tissue L-BAIBA/FGF23 (L-beta-aminoisobutyric acid/fibroblast growth factor 23) signaling axis as a therapeutic target for enhancing musculoskeletal remodeling in aging populations. The research project, with a completion date of May 31, 2029, will generate...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Henry Ford Health + Michigan State University Health Sciences a Project Grant totaling $3,062,355 under the Aging Research program (CFDA 93.866) to advance understanding of cerebral waste clearance mechanisms during Alzheimer's disease progression. The research initiative, spanning from September 15, 2025 through August 31, 2029, will optimize and validate detection of microvessels within the cerebral vascular,...
- Federal Project Grant Award Summary Rutgers, The State University received a $573,035 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 15, 2026, with a completion date of January 31, 2031. This award supports research investigating the control of cerebrospinal fluid (CSF) hydrodynamics and brain-waste clearance mechanisms relevant to neurodegeneration and aging. The project delivers scientific research directed toward...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis $624,837 under the Aging Research program (CFDA 93.866) on February 15, 2026, to support research investigating the MR1/MAIT (Mucosal-Associated Invariant T) cell axis in Alzheimer's disease (AD) pathology. The award period extends through January 31, 2031. The research project seeks to advance understanding of how the MR1/MAIT cell axis contributes to neuroinflammation in AD through a...
- This $1,246,362 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Rush University Medical Center aims to elucidate the morphology and compositional changes of the perivascular pia mater (PVS PIA) in the human brain across aging and Alzheimer's disease. The 3-year project will leverage clinical and pathological data from the Rush Religious Orders Study and Memory and Aging Project to map PVS PIA anatomy using advanced microscopy techniques. Key...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $2,317,887 will be used by Indiana University Indianapolis to map paravascular cerebrospinal fluid (PCSF) signatures associated with healthy aging, aging with hypertension, and Alzheimer's disease (AD). The researchers will leverage dynamic diffusion-weighted imaging, a novel neuroimaging technique, to quantify PCSF dynamics and volume near major arteries - a key component of the glymphatic system that regulates fluid clearance in the brain. This work aims to determine whether fluid clearance function shows similar or distinct alterations across healthy aging, hypertension, and AD, which could inform development of new disease detection and treatment approaches. As a sub-award, Purdue University will provide expertise in multimodal imaging and paravascular fluid dynamics analysis to support this research. The project period runs from September 2023 to August 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 9/8/23 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
10599S | Purdue University | Project Grant RF1AG083762 | $43.6k | 11/21/25 |