The National Institutes of Health's National Institute on Aging awarded a $5,063,226 Project Grant to Brigham and Women's Hospital Inc. under the Aging Research program (CFDA 93.866) for the period of September 1, 2022 through August 31, 2025. The grant funds research to analyze the functional role of glial cells in tauopathy and Alzheimer's disease. Researchers will use genetic approaches in Drosophila to identify glial proteins and pathways that influence tau neurotoxicity in aging adult fly...
This Project Grant award, identified as R01AG083943, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program. The $771,518.10 award supports research conducted by Brown University to elucidate the role of the protein CHI3L1/YKL-40 in the pathogenesis of Alzheimer's disease (AD). The key objectives of this 5-year project are: 1) to define the signaling mechanism by which CHI3L1 governs neurodegeneration caused by glial cell activation, and 2) to...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets; 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $528,876 to Emory University to conduct research investigating the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The 5-year project, beginning June 1, 2025, aims to develop new analytical tools that can integrate transcriptome-wide and proteome-wide association studies with genome-wide association data...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $3,018,210 to Baylor College of Medicine under the Aging Research program (CFDA 93.866). The grant funds research to functionally dissect a promising transcriptional regulatory network linked to glutamate excitatory signaling that is downregulated in Alzheimer's disease and enriched for suppressors of neurodegeneration. Researchers will perform genetic manipulations in...
This Project Grant award of $319,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brown University aims to identify the rate of normative cognitive aging in adults and determine how much faster cognitive aging occurs in individuals with Alzheimer's disease or related dementias. Specifically, the project will use data from the Children of the Depression (CODA) cohort of the Health and Retirement Study to establish a latent variable estimate of general cognitive...
The federal Project Grant award R21AG087875, totaling $239,122.00, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Yale University. The grant supports a team science approach to integrate machine-learning models and functional genomics to study aging in the context of Alzheimer's disease. Key objectives include developing a cell-type specific regulatory network model for normal brain aging and Alzheimer's brain aging, and generating an empirical dataset to...
This $6,226,692 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program supports research examining the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to use a mouse model to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the pathological hallmarks of AD. Key objectives include tracking early...
The National Institute on Aging (NIA) awarded a $619,681 Project Grant under the Aging Research (CFDA 93.866) federal grant program to The Leland Stanford Junior University. The grant titled "Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models" aims to develop innovative tools and methodologies to study the complex genetic interactions underlying Alzheimer's disease pathogenesis. Key products include...
This $1,157,896 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at Brown University focused on elucidating the mechanistic basis of transketolase-mediated suppression of neurodegeneration in amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The grantee will study multiple models of ALS/FTD using Drosophila genetics and analyze molecular readouts such as redox state, autophagy,...
Brown University received a $320,082.72 project grant award from the National Institutes of Health's National Institute on Aging on January 15, 2021 to complete work by August 15, 2021. The grant supports research to characterize the transcriptome and epigenome of genetic models of Alzheimer's disease in Drosophila melanogaster. Using computational biology approaches and next-generation sequencing techniques, the researchers will identify characteristic transcriptional and chromatin state changes that occur in the brain during Alzheimer's disease. They will also determine how these are modified during normal aging and disease progression. Insights gained from this work are expected to further understanding of the molecular basis of both aging and Alzheimer's disease etiology and progression. The research is funded through the National Institute on Aging's Aging Research program (CFDA 93.866), which supports biomedical, social and behavioral research directed toward greater understanding of the aging process and diseases of aging.