This $1,157,896 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at Brown University focused on elucidating the mechanistic basis of transketolase-mediated suppression of neurodegeneration in amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The grantee will study multiple models of ALS/FTD using Drosophila genetics and analyze molecular readouts such as redox state, autophagy, and metabolite and transcriptomic profiling to obtain a global biomarker profile of disease versus suppressed states. This comprehensive understanding of changes correlating with restored neuronal function and motor activity in ALS/FTD may highlight targets for therapeutics to prevent neuronal and cognitive decline associated with ALS/FTD.
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