This $461,146 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project at Yale University to investigate the disruption of astrocytes, a key cell type in the brain, across different stages of Alzheimer's disease pathology. The project aims to utilize advanced imaging techniques to longitudinally track changes in astrocytic signaling and its coupling with neuromodulatory systems, such as noradrenergic signaling, in two genetic models of...
This $6,226,692 project grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to The Trustees of Columbia University in the City of New York. The grant will support research examining the role of neuronal hyperexcitability and proteostasis (regulation of protein life cycle) in the early progression of Alzheimer's disease (AD). The study aims to track electrophysiological changes and protein accumulation in the locus coeruleus...
This federal Project Grant award, valued at $2,288,327 and provided by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, supports research to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patient samples. The project aims to integrate polygenic risk scores for AD with multi-omic profiling of MCI patient-derived induced neurons (iNs) to better understand the early trajectory of...
This $156,000 federal Project Grant award, issued by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research by Thomas Jefferson University (Sidney Kimmel Medical College) to develop a novel therapeutic strategy for Alzheimer's disease (AD). The key objectives are to: 1) Generate intrabodies to neutralize the RNA:DNA hybrids associated with AD pathogenesis, and 2) Validate the efficacy of these intrabodies in suppressing the cGAS-STING pathway activation in cerebral...
This $2,351,870 Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), aims to develop novel analytical approaches to dissect cell-cell communication among microglia, astrocytes, and neurons, and understand how these communications are dysregulated during Alzheimer's disease (AD) progression. Key products and services to be delivered under this grant include: Developing network-based models and statistical methods to identify...
Brown University received a $320,082.72 project grant award from the National Institutes of Health's National Institute on Aging on January 15, 2021 to complete work by August 15, 2021. The grant supports research to characterize the transcriptome and epigenome of genetic models of Alzheimer's disease in Drosophila melanogaster. Using computational biology approaches and next-generation sequencing techniques, the researchers will identify characteristic transcriptional and chromatin state...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $442,357 aims to elucidate the molecular mechanisms underlying the neurodegenerative reprogramming of microglia, the brain's primary immune cells, in Alzheimer's disease (AD). The key research objectives are to: 1) determine the mechanisms by which the Integrated Stress Response (ISR) pathway triggers chromatin remodeling in microglia, 2) test whether ISR exacerbates stressed microglia...
This $2,336,396 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to investigate the mechanisms by which nasal administration of anti-CD3 antibodies can ameliorate disease in a mouse model of Alzheimer's disease (AD). The key research objectives include: Determining the pharmacokinetics, optimal dosing, and mechanisms by which nasal anti-CD3 modulates microglia and astrocytes in the 3xTG AD mouse model. This will involve quantifying...
This federal Project Grant award of $10,847,672 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the J. David Gladstone Institutes to conduct research on the mechanisms of cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The award will fund a multidisciplinary research effort to profile human postmortem brain samples using advanced single-cell and spatial genomics techniques, while also leveraging mouse models to...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to better understand the role of microglia, the brain's immune cells, in the progression of Alzheimer's disease (AD). The University of Washington is the prime awardee and will leverage novel explainable AI techniques and human-induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes occurring early in AD. Specific objectives include using AI to identify...