This $459,076 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the early transcriptional and pathological changes in vulnerable brain regions during the prodromal stage of Alzheimer's disease (AD). The project will leverage single-nucleus RNA sequencing and targeted mass spectrometry analysis of postmortem brain samples from individuals with early-stage AD pathology to profile gene expression changes and identify...
This $125,896 Project Grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a research project led by The Washington University in St. Louis. The project aims to utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and Alzheimer's disease (AD) human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience pathways across genetic, epigenomic,...
This $766,467 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to the Georgia State University Research Foundation Inc. The funding supports the development of flexible multivariate models that can jointly analyze multi-scale neuroimaging and genomic data to better understand Alzheimer's disease and related dementias (ADRD). The proposed models aim to address key limitations of existing multivariate data fusion...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The 5-year project aims to improve understanding of AD's causes, identify new therapeutic targets, and develop new tools for studying protein dysfunctions in AD. Key objectives include applying...
This federal Project Grant award of $125,373 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify genetic associations between Alzheimer's disease (AD) and cardio-cerebrovascular risk factors (CVRFs) such as hypertension and diabetes. The overarching goal is to elucidate the interplay between genes, CVRFs, and AD risk, with the potential to reveal novel molecular targets for prevention and treatment strategies tailored to diverse racial/ethnic...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research aims to investigate the mechanisms by which the Alzheimer's disease risk factor APOE4 interacts with sex and aging to drive neuronal dysfunction and cognitive decline. The $804,450 award to the J. David Gladstone Institutes will fund a multi-level research effort leveraging advanced techniques like single-nucleus RNA sequencing and in vivo brain activity monitoring. The key objectives are to:...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,104,254 to the HudsonAlpha Institute for Biotechnology to identify transcription factors that regulate the expression of the MAPT gene, which is associated with neurodegenerative diseases like Alzheimer's. The key objectives are to: 1) Use CRISPR-based screens to find transcription factors that can modulate MAPT transcription, 2) Determine which trans-regulatory elements directly interact...
This federal Project Grant award under the National Institute on Aging's Aging Research program (CFDA 93.866) provides $913,225 to St. Jude Children's Research Hospital Inc. to conduct a comprehensive research project on Alzheimer's disease (AD) and related dementias (ADRD). The project aims to systematically characterize the role of U1 small nuclear ribonucleoprotein (U1 SNRNP) proteinopathy and its impact on RNA splicing dysfunction in the pathogenesis of AD/ADRD. The research will leverage...
This National Institute on Aging R01 Project Grant Award (CFDA 93.866 - Aging Research) provides $745,092 to the University of Virginia to conduct research on the epitranscriptomic mechanisms underlying the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The key objectives are to: 1) Decode the epitranscriptomic profiles impacted by tau pathology using m6A DART-seq, 2) Determine the role of RNA methylation in AD pathogenesis using 3D neuron-glial brain assembloids, and 3)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $805,738 in funding to the Battelle Memorial Institute's Pacific Northwest National Laboratory Division, operating as Pacific NW National, to conduct research on the role of brain lipoproteins in the development of Alzheimer's disease. The key objectives of this 5-year project are to: 1) assess the impact of different apolipoprotein E (ApoE) isoforms on the distribution, composition, and...