Project Grant R01NS143202

Award Date 6/1/25
Completion Date 5/31/30
Dollars Obligated $869K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Boston, MA 02118, USA
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The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $909,090 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Scripps Research Institute in La Jolla, CA. This grant will fund research focused on developing a therapeutic strategy to treat prion diseases, a rare class of neurodegenerative disorders. The research aims to activate macroautophagy, a cellular process that can...
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The federal Project Grant award R01NS143202, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on understanding the cellular and molecular mechanisms underlying hereditary prion diseases, particularly Creutzfeldt-Jakob disease caused by the E200K mutation in the PRNP gene. The $869,478 award, valid from June 1, 2025 to May 31, 2030, will enable researchers at Trustees of Boston University to utilize induced pluripotent stem cell (iPSC) approaches to analyze the properties and toxicity of mutant prion proteins in iPSC-derived neurons and astrocytes, investigate how neuronal-glial interactions contribute to disease pathogenicity, and identify protective genetic variants in "super-resilient" E200K carriers. This research aims to elucidate fundamental mechanisms of neurodegeneration in prion diseases and uncover potential therapeutic targets with relevance to other neurodegenerative disorders like Alzheimer's disease.

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