Project Grant R01GM155872

Award Date 8/1/24
Completion Date 5/31/28
Dollars Obligated $323K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60611, USA
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This $322,962 project grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to uncover the link between prions and BAF protein complexes and their role in transcription regulation and cellular phenotypes. Key objectives include:

  1. Characterizing variants of the [SWI+] prion and their distinct transcriptomic and phenotypic effects.
  2. Examining how [SWI+] alters the structure and activities of the SWI/SNF complex, induces abnormal protein interactions and aggregation, and leads to transcriptomic/phenotypic changes.
  3. Investigating if BAF proteins or their mutants exhibit prion-like behaviors.

The research will employ a range of techniques, including genetic manipulations, biochemical assays, RNA-seq, ChIP-seq, mass spectrometry, and cellular studies. This work is expected to advance the understanding of prion-mediated cellular activities and their link to diseases, with potential implications for developing novel therapeutic strategies.

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