The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $909,090 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Scripps Research Institute in La Jolla, CA. This grant will fund research focused on developing a therapeutic strategy to treat prion diseases, a rare class of neurodegenerative disorders. The research aims to activate macroautophagy, a cellular process that can...
The University of California, San Diego (UCSD) has been awarded a $434,500 Project Grant by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This 2-year grant will support research to determine the signaling pathways activated by prion protein in human induced pluripotent stem cell (iPSC)-derived neurons. The research aims to establish the sequence of intracellular...
This $322,962 project grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to uncover the link between prions and BAF protein complexes and their role in transcription regulation and cellular phenotypes. Key objectives include: Characterizing variants of the [SWI+] prion and their distinct transcriptomic and phenotypic effects. Examining how [SWI+] alters the structure and activities of the...
The University of California, San Diego (UCSD) received a $563,313 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award, spanning from September 2024 to June 2029, will support research to characterize the activity of cellular prion protein (PrPC) and the LRP1/NMDA-R receptor system in regulating neuroinflammation in diverse...
The National Science Foundation Division of Environmental Biology awarded a $358,777 Project Grant to the College of William and Mary under the Biological Sciences federal grant program (CFDA 47.074) to fund collaborative research from July 2022 to June 2026. The research aims to advance understanding of how natural selection impacts prions, which are protein-based infectious agents that can cause diseases like mad cow disease, at multiple levels from molecules to biological communities....
The federal Project Grant award R35NS142868, totaling $897,250.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports an 8-year research program at St. Jude Children's Research Hospital to study the role of biomolecular condensates, such as ribonucleoprotein (RNP) granules, in governing RNA metabolism and the pathogenesis of...
This federal Project Grant award of $597,573.00 was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports advanced structural and dynamic studies of large protein and protein-nucleic acid complexes and assemblies that play key roles in human health and disease. The research aims to provide atomic-level insights into the structure, dynamics, interactions, and function of chromatin...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will provide $655,329 to Albert Einstein College of Medicine to investigate the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The 5-year research project aims to identify causal genetic variants that regulate GPNMB...
This Project Grant award from the National Institute on Aging (NIA), with CFDA Program #93.866 Aging Research, provides $2,898,854 to the University of Southern California (USC) to investigate the molecular mechanisms by which amyloid and prion-like proteins accumulate during aging. The research aims to test the hypothesis that transcription errors induced by DNA damage generate these problematic proteins, which may contribute to neurodegenerative diseases like Alzheimer's. The project...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program is funding research at the Research Foundation of the City University of New York (RFCUNY), Brooklyn College, to elucidate the epigenetic mechanisms through which prions contribute to cellular adaptation in yeast. The $700,000 project, running from August 2024 to July 2027, aims to: (1) map changes in histone modifications associated with the [PIN+] prion; (2) determine the levels,...