The National Science Foundation (NSF) awarded a $955,876 Project Grant to Northwestern University to investigate the role of prion-mediated epigenetic regulation in the budding yeast, Saccharomyces cerevisiae. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to examine how two different yeast prions, [SWI+] and [MOT3+], interact and impact global transcription and protein homeostasis. Using advanced multi-omics techniques, the research program will identify...
This Project Grant award of $229,840.00 from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program supports research at Brandeis University to investigate how a protein called HP1 helps cells maintain epigenetic memory. The project will use the fission yeast model organism to pursue three key objectives: (1) engineer synthetic H3K9me binding modules to test the influence of genome compartmentalization on epigenetic memory, (2) determine how...
The National Science Foundation Division of Environmental Biology awarded a $358,777 Project Grant to the College of William and Mary under the Biological Sciences federal grant program (CFDA 47.074) to fund collaborative research from July 2022 to June 2026. The research aims to advance understanding of how natural selection impacts prions, which are protein-based infectious agents that can cause diseases like mad cow disease, at multiple levels from molecules to biological communities....
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award provides $240,000 in funding from July 1, 2024 to June 30, 2027 to support a postdoctoral research fellowship investigating the molecular mechanisms that enable adaptation of Saccharomyces cerevisiae yeast populations to complex environmental stressors. The research aims to reveal evolutionary dynamics resulting from varying levels of environmental complexity, with the goal of improving...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $322,962 to Northwestern University to conduct research on understanding the role of prion-mediated transcriptional modifications and cellular phenotypes. The key objectives of this 4-year project are to: 1) characterize variants of the [SWI+] prion and their distinct transcriptomic and phenotypic effects; 2) examine...
This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $949,953 Project Grant to the Research Foundation Of The City University Of New York, doing business as Rfcuny - Hunter College, from August 1, 2023 to July 31, 2026. The grant, funded under the Biological Sciences program (CFDA 47.074), will support research to identify molecular interactions and build a detailed model of translational regulation, specifically examining the role of eIF3 and 4E-BP in...
This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
This $869,478 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to elucidate the fundamental mechanisms of neurodegeneration in hereditary prion diseases. The 5-year project, awarded to Trustees of Boston University's Medical Campus starting on June 1, 2025, will: Analyze the properties of the E200K prion protein mutation in induced...
This federal Project Grant award of $597,573 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports structural and dynamic studies of large protein and protein-nucleic acid complexes and assemblies that play key roles in human health and disease. The primary objectives are to: (1) provide atomic-resolution insights into the structure, dynamics, interactions, and function of nucleosomes and large nucleosome arrays...