This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $682,493 to the Albert Einstein College of Medicine to elucidate the role of aberrant histone acetylation in the pathogenesis of Parkinson's disease and related synucleinopathies. The research involves utilizing a human pluripotent stem cell-based discovery platform...
This federal Project Grant award in the amount of $684,451 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders supports a comprehensive research effort to advance understanding and treatment of Parkinson's disease. The project aims to: Identify Parkinson's disease progression subtypes through integrative analysis of longitudinal clinical, transcriptomic, and neuroimaging data...
This federal Project Grant award of $231,255 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to identify the tissue source and functional properties of plasma-derived alpha-synuclein strains associated with Parkinson's disease (PD). The five-year grant, awarded to the University of Pennsylvania, aims to use extracellular vesicles to uncover the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a systematic investigation of disease-associated, regulatory variation and its impact on the risk and progression of Parkinson's disease (PD). The $635,430 award will fund research to: 1) Define chromatin and transcriptional signatures in PD-vulnerable dopaminergic neurons over...
This $1,002,148 federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the role of autophagy, a cellular mechanism for clearing damaged organelles and harmful materials, in neurological diseases like Parkinson's, Alzheimer's, and ALS. The research aims to determine how the regulation of...
This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This $2,768,769 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the influence of the GBA1 gene on the regulation, trafficking, and maturation of key lysosomal proteins involved in the metabolism of alpha-synuclein. The research will use wildtype and isogenic iPSC-derived neurons to examine how GBA1 mutations affect alpha-synuclein degradation, neuronal release, and the accumulation of alpha-synuclein species found in Lewy...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research examining the effects of the Parkinson's disease associated protein LRRK2 on lysosomal function and inflammatory activity in microglia. The $227,205 award will fund a research project utilizing induced pluripotent stem cell-derived microglia to...
This $2,208,982 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the role of interleukin-13 (IL-13) and its receptor IL-13Rα1 in the development of Parkinson's disease (PD). The researchers at the San Diego Biomedical Research Institute aim to determine the molecular and cellular mechanisms by which IL-13 and...