This Project Grant award, with a total funding amount of $909,090, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research aimed at developing a therapeutic strategy to treat prion diseases, a rare class of neurodegenerative disorders. Specifically, the grant will fund investigations into a small molecule compound, A5, that activates macroautophagy to clear neurotoxic prion protein aggregates in neuronal axons. The research, conducted by the Scripps Research Institute in La Jolla, CA, will assess the efficacy of A5 in neuronal and mouse models of familial and infectious prion disease, as well as elucidate the mechanism of action of A5. The award period spans from Dec 15, 2024 to Nov 30, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $909.1k | 12/12/24 |