Project Grant R01NS136112
Award Date
9/20/24
Completion Date
6/30/29
Dollars Obligated
$1.7M
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
Similar Awards
The University of California, San Diego (UCSD) has been awarded a $434,500 Project Grant by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This 2-year grant will support research to determine the signaling pathways activated by prion protein in human induced pluripotent stem cell (iPSC)-derived neurons. The research aims to establish the sequence of intracellular...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $869,478 to Boston University Medical Campus to conduct research on the mechanisms of neurodegeneration in hereditary prion diseases. The research aims to analyze the properties of the E200K prion protein variant in iPSC-derived neurons and astrocytes, examine how...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to investigate a therapeutic strategy to treat prion diseases, a class of rare neurodegenerative disorders. The $909,090 award to the Scripps Research Institute aims to develop and test a small molecule called A5 that activates autophagy, a cellular...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $238,500.00 to the University of California, San Diego (UCSD) to develop a novel phosphorodiamidate morpholino oligonucleotide (PMO) therapeutic targeting amyloid precursor protein (APP) for the treatment of Alzheimer's disease. The project aims to generate a highly...
This $3,845,311 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research at the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using patient-derived induced neurons (iNs). The project aims to better understand the mechanisms that cause mild cognitive impairment (MCI) and the progression to AD, integrating multi-omic analysis of MCI patient-specific iNs with polygenic risk scores....
This Project Grant award, issued by the National Institute on Aging under CFDA 93.866 - Aging Research, aims to elucidate the molecular mechanisms underlying the neurodegenerative reprogramming of microglia, the brain's resident immune cells, in Alzheimer's disease (AD). The $442,357 grant will fund research to determine how cellular stress signaling pathways, specifically the Integrated Stress Response (ISR), epigenetically reprogram microglia in a way that exacerbates their neurodegenerative...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,830,581 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The grant supports in-depth characterization of the mechanism of action of a new macrocycle molecule called RAPIREON, which selectively activates the nuclease activity of the IRE1 protein in the unfolded protein response (UPR) pathway....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $126,956 to the University of California, San Diego (UCSD) to conduct research on generating new neurons in the aging adult brain. The key objectives are to: Use single cell spatial transcriptomics to define the cellular pathway and molecular mechanisms underlying the conversion of glial cells into functional replacement neurons in the aged mouse brain. This approach was previously...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This federal Project Grant award for $1,275,512 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research conducted by the University of California, San Francisco (UCSF) to investigate how progranulin species impact the accumulation of the TDP-43 protein in neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementia, and limbic-predominant age-associated TDP-43 encephalopathy. The research aims to determine how changes in the...