The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, a $2,554,313 federal Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant, which runs from Sep 1, 2023 to Aug 31, 2026, will support research to determine if targeted in vivo manipulations of local circuit control...
The federal Project Grant award in the amount of $4,245,501.00 from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program supports research at Brandeis University to unravel the synaptic and circuit mechanisms underlying a plasticity-driving instructive signal in the brain. The project aims to determine how the medial entorhinal cortex layer 3 (MEC3) produces a context-specific target signal that drives behavioral timescale synaptic plasticity...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $466,757 to the University of Texas at Austin to conduct research on the synaptic plasticity mechanisms that protect and refine local neural circuits in the brain. The goal is to understand how synapse structure supports learning and memory, with a focus on dendritic spines and the active zones where neurotransmitter release occurs. The...
The University of Chicago received a $3.89 million Project Grant from the National Institutes of Health National Institute of Neurological Disorders and Stroke under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program. The grant will fund research from August 2022 through August 2025 to directly measure and manipulate the spiking activity of locus coeruleus and ventral tegmental area axons in the hippocampus of mice during hippocampal-dependent...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $781,119 to The Regents of the University of California, San Francisco (UCSF) to conduct research on "Dissecting the Circuits and Population Dynamics that Represent Unconditioned and Conditioned Stimuli in the Ventral Hippocampus". The research aims to understand how ventral CA1 neurons in the hippocampus acquire, update, and...
This federal Project Grant award of $880,000 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Northwestern University to investigate how the unique dynamic properties of mossy fiber (MF) synapses in the hippocampus contribute to the ability of mice to distinguish similar spatial representations. The goal is to test whether eliminating a specialized...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $225,400.00 over 5 years starting January 1, 2025 to The Regents of the University of California, San Francisco (UCSF). The project aims to investigate hippocampal-cortical neuronal mechanisms underlying memory impairment in temporal lobe epilepsy. Specifically, it will use...
This federal Project Grant award of $354,600.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will support the development of novel methodologies for simultaneous, distributed perturbation of multiple cortical regions using patterned light in head-fixed mice. The goal is to infer how large-scale patterns of cortical activity underlie...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $828,335 to the University of Chicago to investigate the roles of inhibitory and disinhibitory neural circuits in the formation, stabilization, and competition of neural assemblies in the cortex. The project aims to experimentally test theoretical...
This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...