This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research conducted by Dr. Sharon Chiang at the University of California, San Francisco (UCSF) to investigate hippocampal-cortical mechanisms of memory consolidation in temporal lobe epilepsy. The $225,400 award, effective from January 1, 2025 to December 31, 2029, will enable Dr. Chiang to leverage in vivo single neuron recordings, real-time neurofeedback, and electrical stimulation in an epilepsy rat model to examine abnormalities in memory replay and formation of cortical memory-supporting neuronal ensembles. This research aims to generate fundamental knowledge about the role of these neural circuitry steps in memory impairment associated with temporal lobe epilepsy and explore potential targeted therapeutic interventions. The award also includes a career development plan for Dr. Chiang to acquire additional expertise in flexible polymer probes, closed-loop neurotechnology, and other techniques under the guidance of a multidisciplinary mentorship team.
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