The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $676,789 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program to the Buck Institute for Research on Aging. The grant supports research to investigate the in vivo impact of N6-methyladenosine (m6A), a common mRNA modification, on synaptic function and neurotransmitter release. The research aims to establish critical roles for the epitranscriptome in...
This Project Grant award of $244,154, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Albert Einstein College of Medicine to investigate the regulation of presynaptic gene transcripts during synaptogenesis. The research, conducted over the period from September 1, 2024 to June 30, 2027, will leverage the genetic accessibility and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $580,045.00 to The Trustees of the University of Pennsylvania to investigate the role of the chromatin methyltransferase DOT1L in neuronal function and how its disruption leads to neurodevelopmental disorders. The research aims to elucidate the mechanisms through...
This Project Grant award of $270,434, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by Princeton University to investigate the spatiotemporal regulation of mRNA and its role in neuronal remodeling during morphogenesis. The project will leverage Drosophila models to characterize the localization and motility of the chickadee (chic)...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $457,714 to the University of California, Davis to conduct research on the role of post-transcriptional regulation on cortical cell fate specification. The research aims to uncover the dynamics of microRNA (miRNA) expression and the mRNAs targeted by miRNA pairs in neural...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,181,744.00 to The Trustees of the University of Pennsylvania to conduct research on the molecular and circuit mechanisms by which neurexin1 (NRXN1) gene mutations contribute to goal-directed dysfunction across neuropsychiatric disorders. The 5-year project, starting on September 25, 2024 and ending on May 31, 2029, will employ...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $812,500 in funding to The Trustees of the University of Pennsylvania (UPenn) to conduct research on RNA regulation and noncanonical translation between cell states. The research aims to map post-transcriptional regulation and the unannotated proteome, including RNA localization and modifications, to better understand how...
The National Institutes of Health's Office of the Director awarded a $2,925,000 Project Grant to The Trustees of the University of Pennsylvania under the Trans-NIH Research Support program (CFDA 93.310) to develop genomic tools for massively parallel recording of signaling activity at cellular resolution in a brain-wide manner. The University of Pennsylvania will utilize CRISPR/Cas tools to record signaling inputs in each cell's genome and analyze these signals at high-throughput using...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,503,949 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Rockefeller University. The grant, awarded on May 1, 2025, supports a research project titled "Applying RNA Logic in Space and Time to Neurologic Disease". The project aims to develop new techniques and concepts to discover therapeutic targets for neurological diseases by studying...