This $670,600 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to better understand the role of microglia, a type of immune cell in the brain, in the onset and progression of Parkinson's disease (PD). The research aims to determine whether increased density of the colony stimulating factor 1 receptor (CSF1R), a marker of...
This $837,500 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research to characterize the properties and performance of the PET radiotracer [18F]3F4AP for detecting and quantifying demyelination and cerebral perfusion in Alzheimer's disease, mild cognitive impairment, and cognitively normal individuals. The project aims to conduct the first full pharmacokinetic evaluation of [18F]3F4AP in human subjects and validate...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports a $694,369 research study to investigate the neural mechanisms underlying cognitive decline in multiple sclerosis (MS). The study will utilize a multi-scale, multi-modal imaging approach to examine the association between cognitive function and changes in brain...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $647,782 to the San Diego Biomedical Research Institute to conduct research on evaluating the therapeutic potential of hypoxia mimetics in inflammatory demyelinating disease, specifically multiple sclerosis (MS). The key objectives of this 5-year research project are to: 1)...
The National Institute on Aging (NIA) awarded a $455,009 Project Grant under the Aging Research program (CFDA 93.866) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop an [18F]-labeled amphiphilic PET probe capable of crossing the blood-brain barrier to detect CD206+ anti-inflammatory microglia/macrophages in Alzheimer's disease (AD). The goal is to create a non-invasive imaging method to track these key cell types and monitor their changes...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,969,644 to develop a novel positron emission tomography (PET) imaging probe targeting myeloperoxidase (MPO) activity for detecting neuroinflammation in neurodegenerative diseases. The Massachusetts General Hospital will design and screen potential PET agents for detecting MPO activity in the brain, characterize and validate candidate MPO PET...
This $431,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports the development of an innovative Positron Emission Tomography (PET) molecular neuroimaging technique. The goal is to non-invasively and repeatedly image whole-brain neurocircuitry involved in complex behaviors and cognitive tasks in awake mammals. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $204,156.00 to the Regents of the University of Michigan to study the role of macrophage subpopulations in axon degeneration, nerve inflammation, and regeneration following sciatic nerve injury. The research aims to understand how macrophage efferocytosis, mediated by the...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $812,030 to The Trustees of the University of Pennsylvania to develop and optimize noninvasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The research aims to explore the connections between neuroinflammation, brain glucose hypometabolism, and AD progression using advanced magnetic resonance imaging techniques like...