Project Grant R01MH143147
- The National Institute of Mental Health awarded the University of California, Los Angeles $787,498 under the Mental Health Research Grants program (CFDA 93.242) on July 1, 2026, to characterize HIV persistence and neuroinflammation in central nervous system (CNS) reservoirs in vivo using barcoded HIV tracking, spatial transcriptomics, single-cell RNA sequencing, and integration site analysis. The research investigates the contributions of T cell populations in HIV persistence and inflammation...
- The National Institute of Mental Health awarded the University of Alabama at Birmingham $1.809 million on June 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop novel preclinical models of neuroHIV that incorporate antiretroviral therapy suppression dynamics. The award funds development of next-generation neuroHIV models composed of autologous peripheral human immune cells, relevant human glial cell types, and an intact blood-brain barrier in the context of...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $1,217,055 on July 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate selective inhibition of T cell trafficking to the brain during acute SHIV infection in rhesus macaques. The research leverages a validated nonhuman primate model of HIV neuropathogenesis and persistence to determine how blocking T cell circulation during acute SHIV.D infection affects the...
- The National Institute of Mental Health awarded The Johns Hopkins University $1.106 million on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the effects of broadly neutralizing antibody treatment on neuroinflammation and central nervous system persistence in SIV-ART macaques. The research addresses persistent cognitive impairment in people with HIV despite highly effective antiretroviral therapy, driven by neuroinflammation for which no targeted...
- The National Institute of Mental Health awarded $1,518,208 to Rush University Medical Center on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and employ a human-mouse chimera model for studying HIV infection in the central nervous system and HIV-associated neurocognitive deficits in antiretroviral therapy-treated patients. The award supports research that models the dynamics of HIV crossing the blood-brain barrier into the brain, the resulting...
- The National Institute of Mental Health awarded The University of Texas Southwestern Medical Center $1,645,997 on September 22, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct positron emission tomography imaging research examining microglial proliferation and its relationship to executive function and cognitive control deficits in virally-suppressed people with HIV. The project, titled "Imaging Microglia in Virally-Suppressed HIV," uses [11C]DPA-713...
- The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $793,185 on April 7, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate inactivation of the ISR/ATF4 signaling pathway as a mechanism to stabilize and reduce HIV reservoirs in latently infected cells. The award funds research into how the integrated stress response and ATF4 transcription factor regulate HIV transcription and latency. The project will characterize how...
- The National Institute of Mental Health awarded Drexel University $100,228 on December 16, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on HIV-induced trained immunity in microglia and its contribution to HIV-associated neurocognitive disorders (HAND). The project investigates whether trained immunity—a form of innate immune memory characterized by hyperresponsiveness to secondary inflammatory stimulation—occurs in microglial cells of people living with...
- The National Institute of Mental Health awarded the University of South Carolina $1,016,319 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop multimodal artificial intelligence methods for monitoring and predicting neurocognitive impairment in people with HIV. The project integrates electronic health records, genomic, survey, and imaging data from the National Institutes of Health's All of Us Research Program—a centralized repository with de-identified...
- The National Institute of Mental Health awarded Thomas Jefferson University $431,750 on May 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize the role of DNA-dependent protein kinase (DNA-PK) in HIV latency and transcription within central nervous system microglial cells, the primary CNS reservoir for HIV. The research aims to define the molecular mechanisms by which DNA-PK supports HIV transcription in microglial cells and to test the hypothesis that DNA-PK...
The National Institute of Mental Health awarded the University of Louisville Office of Research & Innovation $910,490 on August 7, 2026, for research investigating the role of the T cell repertoire in viral neuroinvasion and neuropathology in individuals living with HIV on antiretroviral therapy. The award funds Project Grant R01MH143147 under the Mental Health Research Grants program (CFDA 93.242). The research employs single-cell techniques applied to human tissue and macaque central nervous system and peripheral tissue samples to identify unique viral and T cell properties associated with T cell infiltration into the brain, examining how T cell receptor sequence features and viral adaptation influence differential T cell migration and neuroinvasion. The work specifically investigates whether select viral variants reprogram T cell migration, whether T cell differentiation state influences neuroinvasive capabilities across HIV-infected individuals, and whether T cell receptor signatures could identify individuals who would benefit from therapies used in other T cell-mediated neurological disorders such as multiple sclerosis. The research incorporates studies with and without natalizumab, a T cell trafficking inhibitor. Performance is located in Louisville, Kentucky. The performance period extends from August 7, 2026, through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $910.5k | 8/11/26 |