Project Grant R01MH140425
- The National Institute of Mental Health awarded The Leland Stanford Junior University $192,192 on April 15, 2026, to develop an artificial intelligence foundation model for functional neuroimaging that predicts treatment response, stratifies patients, and identifies biotypes in major depressive disorder under CFDA 93.242 (Mental Health Research Grants). The award funds three specific aims. Aim 1 applies pooled functional MRI data from individuals with major depressive disorder to fine-tune a...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $620,848 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a novel neural dynamic model characterizing volatility and rigidity of brain state dynamics in relation to youth externalizing behaviors. The research leverages the large-scale, longitudinal Adolescent Brain Cognitive Development (ABCD) dataset and employs single-trial and state-space models to...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $722,773 under the Mental Health Research Grants program (CFDA 93.242) on July 15, 2026, to develop explainable artificial intelligence frameworks for predicting depression incidents in people with HIV. The research integrates multimodal data from 3,962 people with HIV across multiple longitudinal studies to elucidate bidirectional associations between HIV, depression, and immune dysregulation. The project...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $116,837 on May 4, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate theta burst stimulation delivered during sleep as a neuromodulation approach for treating depression. The research tests whether intermittent theta burst stimulation (ITBS) targeting the dorsolateral prefrontal cortex during non-rapid eye movement sleep produces superior prefrontal plasticity compared to...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $721,645 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify multimodal prognostic markers predictive of psychosis transition in youths at clinical high risk using artificial intelligence and large-scale multimodal data from clinical, cognitive, and neurobiological sources. The recipient will develop and validate an AI-based computational framework combining explainable...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $128,206 on September 1, 2026, under Mental Health Research Grants (CFDA 93.242, Assistance Type: Project Grant) to develop and apply next-generation imaging and perturbation technologies for mapping and manipulating cortex-wide networks during social behavior in autism spectrum disorder models. The funded research addresses cortical network dysregulation in autism by combining ultrasensitive dual-color...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $1,066,793 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026, to develop and validate a personalized repetitive transcranial magnetic stimulation (rTMS) protocol for treatment-resistant depression using electrophysiological biomarkers. The award funds an R61/R33 phased study that will use early local TMS-evoked potentials (EL-TEPs)—measurements of prefrontal excitability—to...
- The National Institute of Mental Health awarded Boston Children's Hospital $153,560 on January 7, 2027, under the Mental Health Research Grants program (CFDA 93.242) to conduct a postdoctoral fellowship examining the relationship between sleep physiology, myelin content, and depressive symptoms in young people ages 9–26 years. The research leverages data from two ongoing R01 studies to investigate two specific aims: understanding the relationship between sleep EEG signatures (spindles and slow...
The National Institute of Mental Health awarded The Leland Stanford Junior University $977,740 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research examining sleep as a predictor of depression onset in adolescence. The research applies a deep-learning framework to two large public longitudinal datasets—the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA; N=624) and the Adolescent Brain Cognitive Development Cohort (ABCD; N=11,800)—to identify constellations of neurobiological, behavioral, and contextual factors that forecast depressive symptoms and major depressive disorder in individual adolescents. The work focuses on sleep as a modifiable intervention target, examining interactions across sociodemographic and environmental factors, cognitive function, personality, neural circuitry, and divergence by sex. Depressive symptoms are grouped according to National Institute of Mental Health Research Domain Criteria (NIMH RDoC) constructs of negative and positive valence. The award recipient is The Leland Stanford Junior University, a private research university in Palo Alto, California. The period of performance runs from September 1, 2026, through May 31, 2031. Place of performance is Palo Alto, California. This is a Project Grant, the standard NIH assistance type for research support in excess of three years and not to exceed five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $977.7k | 9/3/26 |