Project Grant R01MH140868
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $977,740 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research examining sleep as a predictor of depression onset in adolescence. The research applies a deep-learning framework to two large public longitudinal datasets—the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA; N=624) and the Adolescent Brain Cognitive Development Cohort...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $128,206 on September 1, 2026, under Mental Health Research Grants (CFDA 93.242, Assistance Type: Project Grant) to develop and apply next-generation imaging and perturbation technologies for mapping and manipulating cortex-wide networks during social behavior in autism spectrum disorder models. The funded research addresses cortical network dysregulation in autism by combining ultrasensitive dual-color...
- The National Institute of Mental Health awarded the University of Southern California $751,034 on August 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a neuroscience research project examining how the brain processes uncertainty in noisy, dynamically changing environments. The project, titled "Unraveling Neural Mechanisms Underlying Learning in a Noisy, Dynamically Changing World," investigates computational and neural mechanisms by which the brain...
- The National Institute of Mental Health awarded California Institute of Technology $1,417,650 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop instrumentation for synchronized multimodal recording and analysis of human behavior and neural activity during complex, unstructured tasks. The project develops a system to acquire and synchronize behavioral data streams including head-mounted eye tracking to monitor gaze position, egocentric and...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $721,645 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify multimodal prognostic markers predictive of psychosis transition in youths at clinical high risk using artificial intelligence and large-scale multimodal data from clinical, cognitive, and neurobiological sources. The recipient will develop and validate an AI-based computational framework combining explainable...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $767,029 on July 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a multimodal assessment protocol for characterizing restricted and repetitive behaviors in autism spectrum disorder. Stanford will develop three versions of the Dimensional Assessment of Restricted and Repetitive Behaviors (DARB): a computerized adaptive test version to maximize precision and reduce...
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $192,192 on April 15, 2026, to develop an artificial intelligence foundation model for functional neuroimaging that predicts treatment response, stratifies patients, and identifies biotypes in major depressive disorder under CFDA 93.242 (Mental Health Research Grants). The award funds three specific aims. Aim 1 applies pooled functional MRI data from individuals with major depressive disorder to fine-tune a...
The National Institute of Mental Health awarded The Leland Stanford Junior University $620,848 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a novel neural dynamic model characterizing volatility and rigidity of brain state dynamics in relation to youth externalizing behaviors. The research leverages the large-scale, longitudinal Adolescent Brain Cognitive Development (ABCD) dataset and employs single-trial and state-space models to characterize volatility and rigidity of neural circuit dynamics during cognitive tasks in children, their developmental trajectories, and sex differences. Volatility refers to the brain's difficulty sustaining a stable, optimal state during cognitive tasks; rigidity refers to the brain's inertia in disengaging from obsolete states when task demands shift. The work focuses on cognitive control and reward systems where dysfunctions have been linked to externalizing symptoms, aligning with the Research Domain Criteria framework. Externalizing behaviors—marked by weakened impulse control and heightened sensation seeking—are pervasive across neurodevelopmental and psychiatric disorders, and their longitudinal progression is highly predictive of academic and social functioning. Performance occurs at Palo Alto, California, with a period of performance from award date through April 30, 2031. This is a Project Grant, the standard research grant mechanism for NIMH-supported hypothesis-driven investigations with support recommended for up to five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $620.8k | 8/26/26 |