Project Grant K99MH145666
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded the University of California, Davis $123,498 under the Mental Health Research Grants program (CFDA 93.242) on June 5, 2026, to support research improving the quality and acceptability of autism services. The award is structured as a K99 (Pathway to Independence) Project Grant, supporting investigation into the safety, validity, and ethics of early intervention approaches for autism in light of concerns raised by the neurodiversity movement and...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $620,848 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a novel neural dynamic model characterizing volatility and rigidity of brain state dynamics in relation to youth externalizing behaviors. The research leverages the large-scale, longitudinal Adolescent Brain Cognitive Development (ABCD) dataset and employs single-trial and state-space models to...
- The National Institute of Mental Health awarded the University of California, Los Angeles $772,569 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct highly parallel analysis of high-confidence autism spectrum disorder and schizophrenia risk gene mechanisms. The recipient will study approximately 50 risk genes identified as harboring rare, protein-disrupting heterozygous mutations associated with these neuropsychiatric disorders. The work leverages a...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $125,169 on July 30, 2026, under the Mental Health Research Grants program (CFDA 93.242, assistance type: Project Grant) to investigate brain metabolic dysfunction as a mechanism underlying autism spectrum disorder. The project uses non-invasive magnetic resonance spectroscopy to measure brain metabolites as markers of metabolic dysfunction in autistic adolescents relative to non-autistic peers,...
- The National Institute of Neurological Disorders and Stroke, an institute of the National Institutes of Health, awarded The Regents of the University of California, San Francisco $205,200 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into the role of microglia in cortical interneuron development in genetic and environmental disruptions associated with autism spectrum disorder. The work...
- The National Institute of Mental Health awarded the University of Southern California $1.509 million on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop machine learning risk prediction models for persistent adverse mental health outcomes in autistic children and youth, leveraging social determinants of health from electronic health record data. The research uses natural language processing to extract social and ecological factors from clinical notes...
- The National Institute of Mental Health awarded the University of Southern California $855,772 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize autism spectrum disorder heterogeneity using machine learning methods and identify genetic and environmental drivers of clinical variation. The recipient will apply discriminative dimensionality reduction tree (DDRTREE), an unsupervised machine learning model, to construct autism subtypes, continuous subtype...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $767,029 on July 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a multimodal assessment protocol for characterizing restricted and repetitive behaviors in autism spectrum disorder. Stanford will develop three versions of the Dimensional Assessment of Restricted and Repetitive Behaviors (DARB): a computerized adaptive test version to maximize precision and reduce...
The National Institute of Mental Health awarded The Leland Stanford Junior University $128,206 on September 1, 2026, under Mental Health Research Grants (CFDA 93.242, Assistance Type: Project Grant) to develop and apply next-generation imaging and perturbation technologies for mapping and manipulating cortex-wide networks during social behavior in autism spectrum disorder models. The funded research addresses cortical network dysregulation in autism by combining ultrasensitive dual-color head-fixed macroscopy with optogenetic and pharmacological interventions to measure excitatory, inhibitory, and subthreshold voltage activity across the dorsal cortex. The work investigates how local restoration of excitatory-inhibitory balance reshapes large-scale network dynamics and deploys a miniaturized macroscope for cortex-wide imaging and targeted optogenetic stimulation in freely moving mice during naturalistic social interactions. These capabilities establish an experimental platform for causal investigation of network mechanisms underlying behavioral restoration in autism mouse models. Performance of work occurs in Palo Alto, California, with a period of performance from September 1, 2026, through August 31, 2028. K99 awards under this program support up to two-year periods with no renewal provision.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.2k | 9/3/26 |