Project Grant R01MH143936
- The National Institute of Mental Health awarded The Leland Stanford Junior University $128,206 on September 1, 2026, under Mental Health Research Grants (CFDA 93.242, Assistance Type: Project Grant) to develop and apply next-generation imaging and perturbation technologies for mapping and manipulating cortex-wide networks during social behavior in autism spectrum disorder models. The funded research addresses cortical network dysregulation in autism by combining ultrasensitive dual-color...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $620,848 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a novel neural dynamic model characterizing volatility and rigidity of brain state dynamics in relation to youth externalizing behaviors. The research leverages the large-scale, longitudinal Adolescent Brain Cognitive Development (ABCD) dataset and employs single-trial and state-space models to...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $528,000 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support developmental characterization of synapses between neurons and oligodendrocyte precursor cells. The funded research investigates structural, functional, and molecular properties of neuron-OPC synapses, a class of synaptic connections that remain poorly understood despite evidence that oligodendrocyte precursor cells...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded the University of California, Los Angeles $772,569 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct highly parallel analysis of high-confidence autism spectrum disorder and schizophrenia risk gene mechanisms. The recipient will study approximately 50 risk genes identified as harboring rare, protein-disrupting heterozygous mutations associated with these neuropsychiatric disorders. The work leverages a...
- The National Institute of Mental Health awarded University of California, Los Angeles $764,785 under the Mental Health Research Grants program (CFDA 93.242) on July 16, 2026, to investigate context-dependent disease mechanisms in neurodevelopmental disorders, specifically the 16p11.2 chromosomal deletion (16PDEL) implicated in autism, intellectual disability, and ADHD. The project will use a proprietary in vitro human stem cell platform called the Cell Village to conduct high-throughput...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $721,645 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify multimodal prognostic markers predictive of psychosis transition in youths at clinical high risk using artificial intelligence and large-scale multimodal data from clinical, cognitive, and neurobiological sources. The recipient will develop and validate an AI-based computational framework combining explainable...
- The National Institute of Mental Health awarded the University of Pittsburgh $751,430 on August 4, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a multi-omic atlas of dendritic spine morphometry across postnatal development in neurotypical and autism spectrum disorder subjects. The research interrogates trajectories of synaptic protein network features—protein expression, synaptosome levels, and phosphorylation—in the prefrontal cortex and primary visual...
The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal maturation of distinct synapse subclasses and active neuronal properties is central to human neocortical circuit function and whether these processes are impaired in autism. Preliminary findings show that human neocortical glutamatergic synapses cluster into at least five distinct subclasses based on receptor content, with composition diverging across postnatal ages and species, and that active neuronal properties including spike rate adaptation increase through human adolescence, driven by elevation in BK-type calcium-activated potassium channels—properties reduced in children with autism. The proposed study will use conjugate array tomography to delineate human synapse subclasses based on molecular composition and ultrastructure and determine whether a distinctive subclass enriched in AMPA- and NMDA-type glutamate receptors emerges in adolescence, and will use whole-cell patch clamp recordings to measure active neuronal properties in juveniles with and without autism. Work is performed at Palo Alto, California, with a period of performance through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $734.7k | 8/17/26 |